Item#: 124-09 ANTISTREPTOLYSIN O (ASO) Human Concentrate
Product Info:
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| Product Name: | ANTISTREPTOLYSIN O (ASO) Human Concentrate |
|---|---|
| Cat. No: | 124-09 |
| Concentration: | > 1000 u/ml by Beckman Array |
| Expiration: | 1 year |
| Form: | Liquid - .2 micron filtered |
| pH: | 7.0-7.2 |
| Protein: | >3 g/dl by Biuret |
| Source: | Human Plasma |
| Storage: | 2-8 C short term |
Antistreptolysin O CONCENTRATE avaIlable in bulk from 500mls to 5000 mls.
Streptolysin is a hemolysin produced by group A streptococci. In an infected individual streptolysin O acts as a protein antigen, and the patient mounts an antibody response. A rise in anti-streptolysin O level begins about 1 week after infection and peaks 2-3 weeks later. In the absence of complications or reinfection, the anti-streptolysin O ASO titer will usually fall to preinfection levels within 6-12 months. Both clinical and laboratory findings should be correlated in reaching a diagnosis.
Streptococcal infections are caused by bacteria known as Streptococcus. There are several disease-causing strains of streptococci (groups A, B, C, D, and G), which are identified by their behavior, chemistry, and appearance. Each group causes specific types of infections and symptoms. These antibody tests are useful for group A streptococci. Group A streptococci are the most virulent species for humans and are the cause of strep throat, tonsillitis, wound and skin infections, blood infections (septicemia), scarlet fever, pneumonia, rheumatic fever, Sydenham's chorea (formerly called St. Vitus' dance), and glomerulonephritis.
anti-streptolysin O description: Although symptoms may suggest a streptococcal infection, the diagnosis must be confirmed by tests. The best procedure, and one that is used for an acute infection, is to take a sample from the infected area for culture, a means of growing bacteria artificially in the laboratory. However, cultures are useless about two to three weeks after initial infection, so the ASO, anti-DNase-B, and streptozyme tests are used to determine if a streptococcal infection is present.
Antistreptolysin O titer (ASO): The ASO titer is used to demonstrate the body's reaction to an infection caused by group A beta-hemolytic streptococci. Group A streptococci produce the enzyme streptolysin O, which can destroy (lyse) red blood cells. Because streptolysin O is antigenic (contains a protein foreign to the body), the body reacts by producing antistreptolysin O (ASO), which is a neutralizing antibody. ASO appears in the blood serum one week to one month after the onset of a strep infection. A high titer (high levels of ASO) is not specific for any type of poststreptococcal disease, but it does indicate if a streptococcal infection is or has been present.
anti-streptolysin O: Serial ASO testing is often performed to determine the difference between an acute or convalescent blood sample. The diagnosis of a previous strep infection is confirmed when serial titers of anti-streptolysin O aso rise over a period of weeks, then fall slowly. ASO titers peak during the third week after the onset of acute symptoms of a streptococcal disease; at six months after onset, approximately 30% of patients exhibit abnormal titers.
anti-streptolysin O research: An immunoglobulin G myeloma with antistreptolysin activity and a lifelong history of cutaneous streptococcal infection. anti-streptolysin O study: Clinical Immunology and Immunopathology, Volume 9, Issue 1, January 1978, Pages 22-27
anti-streptolysin O study: Interpreting a single antistreptolysin o test: A comparison of the “upper limit of normal” and likelihood ratio methods.anti-streptolysin O Ref: Journal of Clinical Epidemiology, Volume 46, Issue 10, October 1993, Pages 1181-1185
anti-streptolysin O research: The sensitivity and specificity of an agglutination test for antibodies to streptococcal extracellular antigens: A quantitative analysis and comparison of the streptozyme test with the anti-streptolysin O and anti-deoxyribonuclease B tests. anti-streptolysin O ref:The Journal of Pediatrics, Volume 96, Issue 3, Part 1, March 1980, Pages 367-373