Apolipoprotein E (ApoE)
| Product Name | Apolipoprotein E |
| Source | Human Plasma |
| Catalogue Number | 125-30 |
| Purity | > 98% (SDS-PAGE) |
| Form | Liquid |
| Protein | 0.5 - 5.0 mg/mL (Lowry) |
| Formulation | Frozen solution in 20mM Tris, 150mM sodium chloride, 0.5mM EDTA and 0.02% sodium azide, pH 7.4. |
| Related Products | 361-10 - High Density Lipoprotein from human plasma 360-10 - Low Density Lipoprotein from human plasma 360-35 - Cholesterol Concentrate from human plasma |
| Storage | -20°C |
| Recertification | 2 years |
| Infectious Disease Testing | Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV and HBsAg by FDA approved methods. |
| Synonyms | ApoE, Apo E |
| UNSPSC code | 51131909 |
| Molecular Weight | 34,000 - 37,000 |
Lee Biosolutions is a leading producer of Apolipoprotein E (APOE) for research and diagnostic manufacturing.
Technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
Human APOE is 299 amino acids long and transports lipoproteins, fat-soluble vitamins, and cholesterol into the lymph system and then into the blood. Apolipoprotein E, is synthesized principally in the liver, but has also been found in other tissues such as the brain, kidneys, and spleen. In the nervous system, non-neuronal cell types, most notably astroglia and microglia, are the primary producers of Apolipoprotein E, while neurons preferentially express the receptors for APOE.
Apo-E is a 34-37 kDa glycosylated protein and is involved with triglyceride, phospholipid, cholesteryl ester, and cholesterol transport in and out of cells and is a ligand for LDL receptors.
APOE Lipoprotein has also been implicated in immune and nerve degeneration. It has been found to suppress lymphocyte proliferation. Late-onset familial and sporadic Alzheimer disease patients have been found to have a higher occurrence of one of the three common Apo-E isoforms, Apo-E4. The Apo-E4 isoform has been detected in senile plaques and neurofibrillary tangles of Alzheimer disease patients. Apo-E4 is associated with rapid chylomicron-remnant clearance and increased total cholesterol levels.
Lee Biosolutions, Inc
