Item#: 108-10 ARGINASE, Bovine

Bovine Liver L-Arginase is made to order. Minimum order is 250kU. single lot sizes of bovine liver L-Arginase up to 2000kU.

Arginase deficiency is thought to be the least common of the urea cycle disorders. This entity also manifests itself in a fashion somewhat different from other disorders in the group (see Physical). Two separate isozymes of the enzyme arginase have been reported. Type I is found in the liver and contributes the vast majority of hepatic arginase activity, whereas type II is inducible and found in extrahepatic tissues. The disease is caused by a deficiency of arginase type I in the liver.Arginase Ref: Karl S Roth, MD, Chair, Professor, Department of Pediatrics, Creighton University School of Medicine, July 2007 Emedicine

Unit Definition: One unit will convert 1.0 micromoles of L-Arginase to ornithine and urea per minute at pH 9.5 and 37C

Research: Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy. Ref: Eur J Immunol. 2007 Apr;37(4):935-45.

Research: Arginase, Prostaglandins, and Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma. Ref: Clinical Cancer Research 13, 721s-726s, January 15, 2004