Item#: CC-80A Ceruloplasmin, Polyclonal anti-Human Affinity Purified
Product Info:
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| Product Name: | Ceruloplasmin, Polyclonal anti-Human Affinity Purified |
|---|---|
| Ab Concentration: | Typically greater than 1mg/ml |
| Cat. No: | CC-80A |
| Form: | Liquid, PBS pH 7.2 |
| Host: | Chicken |
| Immunogen: | Human Ceruloplasmin |
| Purity: | Affinity Purified |
| Storage: | 2-8?C |
Ceruloplasmin Polyclonal Antibody procedure: Chickens were immunized with highly purified human ceruloplasmin isolated from human serum. The resulting anti-human ceruloplasmin was solid phase absorbed then affinity purified off an antigen containing immunoabsorbant.
Our Polyclonal Antibody anti-Human Ceruloplasmin is suitable for depletion, ELISA and Botting applications.
Western Blots 1:1,000
ELISA coating 1:200-1:500
Polyclonal Antibody chicken anti-human ceruloplasmin BULK Quantities over 100mg of polyclonal anti-human ceruloplasmin single lot sizes
Inquire on our custom polyclonal antibody production. We can host from any species and cross link to your requirements. Custom Polyclonal antibody concentrations available
We also offer Cat. NO: 187-57 Human Ceruloplasmin (CER)antigen
Human Ceruloplasmin (CER) is officially known as ferroxidase or iron(II):oxygen oxidoreductase. Human Ceruloplasmin (CER) is an enzyme synthesized in the liver containing 8 atoms of copper in its structure. Although Human CERULOPLASMIN (CER) is often considered a copper transport protein, this is not its primary function, just as human hemoglobin is not a carrier of iron, although it contains iron. The main carrier for copper in the plasma of humans is albumin. Human Ceruloplasmin enzyme (ferroxidase) catalyzes the oxidation of ferrous iron (Fe2+) to ferric iron (Fe3+), therefore assisting in Human Ceruloplasmin enzyme transport in the plasma in association with transferrin, which can only carry iron in the ferric state
Human Ceruloplasmin enzyme Main Clinical Significance: Diagnosis of Wilsons Disease (hepatolenticular degeneration) also used for detection of Hodgkins Disease, infections, malignancy and trauma
Human CERULOPLASMIN Study: Studies have shown that elevated human serum ceruloplasmin level can be a marker for metabolic stresses associated with MS(insulin resistance syndrome. Human Ceruloplasmin Ref: Metabolism Volume 51,Issue 7,July 2002,Pages 838-842
Human CERULOPLASMIN research: Regulation of human ceruloplasmin(cp,cer) in human hepatic cells by redox active copper: identification of a novel AP-1 site in the ceruloplasmin gene. supports the findings of increased human ceruloplasmin expression in cancers like hepatocarcinoma. Human Ceruloplasmin Ref: Biochem. J. (2007) 402 (135–141)
Human Ceruloplasmin Research: Ceruloplasmin expression and its role in iron transport in C6 cells. Human Ceruloplasmin Ref: Neurochemistry International, Volume 50, Issue 5, April 2007, Pages 726-733
Human Ceruloplasmin Research: Lens epithelial cells synthesize and secrete ceruloplasmin: Effects of ceruloplasmin and transferrin on iron efflux and intracellular iron dynamics. Human Ceruloplasmin Ref: Experimental Eye Research, Volume 83, Issue 4, October 2006, Pages 721-727
Human Ceruloplasmin Research: Retrospective determination of ceruloplasmin in newborn screening blood spots of patients with Wilson disease. Human Ceruloplasmin Ref:
Molecular Genetics and Metabolism, Volume 89, Issues 1-2, September-October 2006, Pages 134-138
Human Ceruloplasmin Research: Plasma copper, iron, ceruloplasmin and ferroxidase activity in schizophrenia. Human Ceruloplasmin Ref:
Schizophrenia Research, Volume 86, Issues 1-3, September 2006, Pages 167-171
Human Ceruloplasmin Research: Does oxidative stress change ceruloplasmin from a protective to a vasculopathic factor?.Human Ceruloplasmin Ref:
Atherosclerosis, Volume 187, Issue 2, August 2006, Pages 238-250
Human Ceruloplasmin Research: Hepatic Iron Overload Associated With a Decreased Serum Ceruloplasmin Level in a Novel Clinical Type of Aceruloplasminemia. Human Ceruloplasmin Ref: Gastroenterology, Volume 131, Issue 1, July 2006, Pages 240-245
Human Ceruloplasmin Research: Ceruloplasmin is an NO oxidase that regulates nitrite homeostasis.Human Ceruloplasmin Ref: Nitric Oxide, Volume 14, Issue 4, June 2006, Page 71