Item#: 321-10 GLUTATHIONE PEROXIDASE Human
Product Info:
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| Product Name: | GLUTATHIONE PEROXIDASE Human |
|---|---|
| Activity: | GPX Enzyme Activity typically > 5 units/ml |
| CAS No: | 9013-66-5 |
| Cat. No: | 321-10 |
| EC No: | 1.11.19 |
| Form: | Frozen Liquid in 4.3mM sodium Phosphate buffer,pH 7.0 |
| Molecular Weight: | 85kda |
| Protein: | Typically greater than .10 mg/ml |
| Source: | Human Red Blood Cells |
| Specific Activity: | Typically greater than 30 u/mg protein |
| Storage: | -20C |
| Synonyms: | Glutathione,hydrogen-peroxide oxido-reductase ,GSH-Px.GPX |
Bulk quantities available for human glutathione peroxidase in 100-5000 unit single lot sizes
Unit Definition: One unit will catalyze the oxidation by hydrogen peroxide of 1.0 micromole of reduced glutathione to oxidized glutathione per min at pH 7.0 at 25c
Human Glutathione Peroxidase contains 0.2mM DTT and sucrose at .25mg/ml
Custom fills for Human Glutathione Peroxidase available. Custom Buffers for Human Glutathione Peroxidase available on bulk orders
Glutathione peroxidase is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. The biochemical function of glutathione peroxidase is to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water.
Human Glutathione Peroxidase (GPX) is a tetrameric protein with 4 atoms of selenium bound to cysteines at the catalytic site. One of the essential requirements is glutathione as a cosubstrate. Glutathione peroxidase reduces H2O2 to H2O by oxidizing glutathione (GSH). Rereduction of the oxidized form of glutathione (GSSG) is then catalysed by glutathione reductase.
Glutathione peroxidase (GPx) catalyzes the reduction of hydroperoxides, including hydrogen peroxides, by reduced glutathione and functions to protect the cell from oxidative damage. With the exception of phospholipid-hydroperoxide GPx, a monomer, all of the GPx enzymes are tetramers of four identical subunits. Each subunit contains a selenocysteine in the active site which participates directly in the two-electron reduction of the peroxide substrate. Human Glutathione Peroxidase REF:Ceballos-Picot, I., Trivier, J., Nicole, A., et al. Age-correlated modifications of copper-zinc superoxide
human glutathione peroxidase study: Role for glutathione peroxidase-4 in brain development and neuronal apoptosis: Specific induction of enzyme expression in reactive astrocytes following brain injury.human glutathione peroxidase reference:
Free Radical Biology and Medicine, Volume 43, Issue 2, 15 July 2007, Pages 191-201/human/glutathione/peroxidase/gpx
human glutathione peroxidase research: Erythrocyte glutathione peroxidase activity and plasma selenium concentration are reduced in maple syrup urine disease patients during treatment.human glutathione peroxidase ref:International Journal of Developmental Neuroscience 17 May 2007/human/glutathione/peroxidase/gpx
human glutathione peroxidase research:Preparation and Kinetics of a Novel Glutathione Peroxidase Mimic—Selenium-modified Hyaluronic Acid
Chemical Research in Chinese.human glutathione peroxidase ref: Universities, Volume 23, Issue 3, May 2007, Pages 325-328/human/glutathion peroxidase/gpx
human glutathione peroxidase research:Pancreatic islet β-cell and oxidative stress: The importance of glutathione peroxidase.human glutathione peroxidase ref:
FEBS Letters,9 April 2007/human/glutathione peroxidase/gpx
human glutathione peroxidase research:Influence of Glucose in the Dialysate on the Activity of Erythrocyte-Glutathione-Peroxidase and Blood Selenium Concentration in Hemodialyzed Patients.human glutathione peroxidase ref:Archives of Medical Research, Volume 38, Issue 3, April 2007, Pages 330-336/human/glutathione peroxidase/gpx
human glutathione peroxidase research:Effects of Acetylcysteine and Probucol on Contrast Medium-induced Depression of Intrinsic Renal Glutathione Peroxidase Activity in Diabetic Rats.human glutathione peroxidase ref:Archives of Medical Research, Volume 38, Issue 3, April 2007, Pages 291-296/human/glutathione peroxidase/gpx
human glutathione peroxidase research:Ebselen treatment reduces noise induced hearing loss via the mimicry and induction of glutathione peroxidase.human glutathione peroxidase ref:Hearing Research, Volume 226, Issues 1-2, April 2007, Pages 44-51/human/glutathione peroxidase/gpx
human glutathione peroxidase research:Glutathione Peroxidase-1 Activity, Atherosclerotic Burden, and Cardiovascular Prognosis.human glutathione peroxidase ref :The American Journal of Cardiology, Volume 99, Issue 6, 15 March 2007, Pages 808-812/human/glutathione peroxidase/gpx
human glutathione peroxidase research:High superoxide dismutase and low glutathione peroxidase activities in red blood cells predict susceptibility of lung cancer patients to radiation pneumonitis.human glutathione peroxidase ref:
Free Radical Biology and Medicine, Volume 42, Issue 2, 15 January 2007, Pages 280-287/human/glutathione peroxidase/gpx
human glutathione peroxidase research:Effects of selenium supplementation on expression of glutathione peroxidase isoforms in cultured human lung adenocarcinoma cell lines.human glutathione peroxidase ref:
Lung Cancer, Volume 55, Issue 1, January 2007, Pages 35-42/human/glutathione peroxidase/gpx
human glutathione peroxidase research:Measurements of the Antioxidant Enzyme Activities of Superoxide Dismutase, Catalase, and Glutathione Peroxidase.human glutathione peroxidase ref:
Methods in Cell Biology, Volume 80, 2007, Pages 379-393/human/glutathione peroxidase/gpx
human glutathione peroxidase research:Correlation between glutathione peroxidase activity and anthropometrical parameters in adolescents with Down syndrome.human glutathione peroxidase ref:
Research in Developmental Disabilities, Volume 28, Issue 1, January-February 2007, Pages 105-108/human/glutathione peroxidase/gpx