HUMAN GLUTATHIONE PEROXIDASE

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Item #: 321-10

Details

Bulk quantities available for human glutathione peroxidase in 100-5000 unit single lot sizes

Unit Definition: One unit will catalyze the oxidation by hydrogen peroxide of 1.0 micromole of reduced glutathione to oxidized glutathione per min at pH 7.0 at 25c

Human Glutathione Peroxidase contains 0.2mM DTT and sucrose at .25mg/ml

Custom fills for Human Glutathione Peroxidase available. Custom Buffers for Human Glutathione Peroxidase available on bulk orders

Glutathione peroxidase is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. The biochemical function of glutathione peroxidase is to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water.

Human Glutathione Peroxidase (GPX) is a tetrameric protein with 4 atoms of selenium bound to cysteines at the catalytic site. One of the essential requirements is glutathione as a cosubstrate. Glutathione peroxidase reduces H2O2 to H2O by oxidizing glutathione (GSH). Rereduction of the oxidized form of glutathione (GSSG) is then catalysed by glutathione reductase.

Glutathione peroxidase (GPx) catalyzes the reduction of hydroperoxides, including hydrogen peroxides, by reduced glutathione and functions to protect the cell from oxidative damage. With the exception of phospholipid-hydroperoxide GPx, a monomer, all of the GPx enzymes are tetramers of four identical subunits. Each subunit contains a selenocysteine in the active site which participates directly in the two-electron reduction of the peroxide substrate. Human Glutathione Peroxidase REF:Ceballos-Picot, I., Trivier, J., Nicole, A., et al. Age-correlated modifications of copper-zinc superoxide

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