Item#: 510-11 RENIN Human
Product Info:
Print This Page (Macintosh users, select "Print" from your browser's "File" menu)
| Product Name: | RENIN Human |
|---|---|
| Activity: | Typically >1 u/ml based on the PRA Assay |
| Cat. No: | 510-11 |
| EC No: | 3.4.23.15 |
| Expiration: | 1 year |
| Form: | Liquid |
| Molecular Weight: | 40,000 |
| Protein: | Typically >0.1 mg Protein/ml by Lowry |
| Purity: | > 90% by NuPAGE gel, 12% Bis-Tris |
| Source: | Human Kidney |
| Storage: | 2-8 C |
HUMAN NATIVE RENIN ENZYME from human kidney BULK QUANTITIES from 10-100 unit single lot sizes. Custom human Renin purification from other species is also available
Human Renin and Human Prorenin products we offer
510-11PR Recombinant Human Prorenin Human
510-11 Native Human RENIN
510-11R Recombinant Human Renin Human
What is Human Renin?
Human Renin, also known as angiotensinogenase, is a circulating enzyme released mainly by juxtaglomerular cells in the JGA of the kidneys in response to low blood volume or low body NaCl content, mediated through the release of prostaglandins. Although human Renin has hormone-like actions, human Renin cleaves a protein precursor in the circulation rather than working on a cellular target.
Human Renin is an important enzyme in the regulation of blood pressure and electrolyte homeostasis and therefore is of great clinical importance. Kinetic and mechanistic functions of human Renin are of importance for the development of hypertension drugs. Plasma renin activity (PRA) is measured as part of the diagnosis and treatment of hypertension.
Human Renin acts as a proteolytic enzyme of the kidney by releasing angiotensin which has a vasoconstrictive action which results in a higher blood pressure. Early detection of Human renin level increases related to a blood pressure increase have shown in research to provide vital prognostic and diagnostic guidelines for evaluating possible surgical treatment especially in renovascular involvement.
Human Renin Research:Functional Characterization of Polymorphisms in the Kidney Enhancer of the Human Renin Gene. Human Renin REF:Endocrinology 2007,Vol.148No.3 1424-1430/renin.
Human Renin Study: Aliskiren, a human renin inhibitor induces persistent renoprotection comparable to ACE inhibition in double transgenic rats (dTGR).Human Renin REF:American Journal of Hypertension,Vol18,Issue 5,A230-A230/renin.
Human Renin research: Blood Pressure-Independent ETA and AT1 Receptor Blocker Effects on the Coronaries of Rats Harboring Human Renin and Angiotensinogen Genes. Human Renin REF:Kidney and Blood Pressure Research 2005;28:134-143/renin.
Human Renin Study: Human Renin is synthesized as an enzymatically inactive prorenin, which is split by limited proteolysis to give the active human renin enzyme. Both human renin and human prorenin is secreted by the kidneys. Circulating human renin concentrations are occasionally raised in nephroblastoma. Human Renin Ref: Plasma Renin activity in Wilms Tumor. 1971,67:197-202/renin.
Human Renin Study: Human Renin is the rate-limiting enzyme in the renin-angiotensin system and thus dictates the level of the pressor hormone angiotensin-II. Human Renin REF: J. Biol. Chem.,Vol.281,Issue 46,35296-35304,Nov17,2006/renin.
Human Renin Study: Association of human renin gene haplotype with essential hypertension in an isolated population.Human Renin REF:Biogenic Amines,Vol19,2,May,2005/renin.
Human Renin Study: The brain renin-angiotensin system is implicated in the regulation of blood pressure and fluid homeostasis.Human Renin REF:2007 American Heart Association, Hypertension,2007/renin.
Human Renin Study: Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats. rats harbor both the human renin and human angiotensinogen genes.Human Renin REF:BMC Cardiovascular Disorders 2002,2:3/renin.
Human renin research:Increased Expression of the Renin–Angiotensin System and Mast Cell Density But Not of Angiotensin-converting Enzyme II in Late Stages of Human Heart Failure. human renin ref:The Journal of Heart and Lung Transplantation, Vo25,Issue 9, Sept2006,1117-1125/human/renin
Human Renin Article: Renin Inhibition as a New Strategy to Combat Cardiovascular Disease.Human Renin REF: Current Hypertension Reviews,Vol3, Nu1,Feb2007,pp. 9-43(5)/renin.
Human Renin Research:Renin-Angiotensin System and Nitric Oxide Synthase Gene Polymorphisms in Relation to Stroke.Human Renin Ref:
American Journal of Hypertension, Vol20,Issue 7,July 2007,P764-770/human/renin
Human Renin Research:Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors.Human Renin Ref:Bioorganic & Medicinal Chemistry Letters,Volu17,Issue 13,1 July 2007, Pages 3575-3580/human/renin
Human Renin Research:Renin–angiotensin-system gene polymorphisms and depression.Human Renin Ref:
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 31, Issue 5, 30 June 2007, Pages 1113-1118/human/renin
Renin Research: Effect of upregulated renin–angiotensin system on per2 and bmal1 gene expression in brain structures involved in blood pressure control in TGR(mREN-2)27 rats.Renin Ref:Brain Research, Volume 1180, 14 November 2007, Pages 29-38/renin/pro-renin/renin study
Renin Research:The (pro)renin receptor: A new addition to the renin–angiotensin system?Human renin/prorenin reference: European Journal of Pharmacology, Volume 585, Issues 2-3, 13 May 2008, Pages 320-324/renin/pro-renin/renin study
Renin Research:From Black and White to Shades of Gray: Race and Renin-Angiotensin System Blockade,Human renin/prorenin reference: Journal of the American College of Cardiology, Volume 51, Issue 19, 13 May 2008, Pages 1872-1873/renin/pro-renin/renin study
Renin Research:Renin angiotensin system blockade and cardiovascular outcomes in patients with chronic kidney disease and proteinuria:Human renin/prorenin reference: A meta-analysis
American Heart Journal, Volume 155, Issue 5, May 2008, Pages 791-805/renin/pro-renin/renin study
Renin Research:Potential role of Renin–Angiotensin-system for tumor angiogenesis in receptor negative breast cancer.Human renin/prorenin reference: Gynecologic Oncology, 18 April 2008/renin/pro-renin/renin study
Renin Research:Inhibition of renin angiotensin system decreases renal protein oxidative damage in diabetic rats,Human renin/prorenin reference: Biochemical and Biophysical Research Communications, Volume 368, Issue 3, 11 April 2008, Pages 528-535/renin/pro-renin/renin study
Renin Research:Outcomes of Acute Kidney Injury Associated With Inhibitors of Renin-Angiotensin System,Human renin/prorenin reference: American Journal of Kidney Diseases, Volume 51, Issue 4, April 2008, Page B47/renin/pro-renin/renin study
Renin Research:Critical roles of (pro)renin receptor-bound prorenin in diabetes and hypertension: sallies into therapeutic approach,Human renin/prorenin reference: Journal of the American Society of Hypertension, Volume 2, Issue 1, January-February 2008, Pages 15-19/renin/pro-renin/renin study
Renin Research:Laughter modulates prorenin receptor gene expression in patients with type 2 diabetes.Human renin/prorenin reference: Journal of Psychosomatic Research, Volume 62, Issue 6, June 2007, Pages 703-706/renin/pro-renin/renin study