Item#: 350-50R LACTATE DEHYDROGENASE ( recombinant )
Product Info:
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| Product Name: | LACTATE DEHYDROGENASE ( recombinant ) |
|---|---|
| Activity: | Typically greater than 200 u/mg |
| Cat. No: | 350-50R |
| Form: | Whilte lyophilized powder |
| Purity: | > 96% by SDS Page |
| Source: | E. coli-Recombinant Chicken Heart |
| Storage: | -20C |
| Synonyms: | (S)-Lacate: NAD+ oxidoreductate, rLDH |
Unit Definition: One unit is defined as 1umol of NAD+ production per minute at 25C, pH 7.0
From cloned LDH-B gene from chicken heart cDNA library
pH stability from 6.0-10.0
Inquire on Bulk quantities of 1-10 million unit single lot sizes
Lacate Dehydrogenase:
Lactate dehydrogenase (LDH) is an enzyme (EC 1.1.1.27) present in a wide variety of organisms, including plants and animals. Lactate Dehydrogenase (LDH) catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. Lactate Dehydrogenase(LDH) can also catalyze the oxidation of hydroxybutyrate, it is occasionally called Hydroxybutyrate Dehydrogenase (HBD).
Determination of serum lacate dehydrogenase activity is one of the most frequently performed assays as an aid in the diagnosis of myocardial and pulmonary infarction. Other conditions, such as megaloblasic anemia, extensive carcinomatois, severe shock and hypoxia, granulocytic or aute anemia, hemolytic anemia, infectious mononucleosis, preogressive musclar dystrophy, hepatitis, cirrhosis, obstructive jaundice, and in delirium tremens are all caused increased activity of lacate dehydrogenase activity
Meningitis and encephalitis
The enzyme is also found in cerebrospinal fluid where high levels of lactate dehydrogenase in cerebrospinal fluid are often associated with bacterial meningitis. High levels of the enzyme can also be found in cases of viral meningitis, generally indicating the presence of encephalitis and poor prognosis.
HIV and elevated LDH
LDH is often measured in HIV patients as a non-specific marker for Pneumocystis jiroveci (formerly Pneumocystis carinii) pneumonia (PCP). Elevated LDH in the setting of upper respiratory symptoms in an HIV patient suggests, but is not diagnostic for, PCP
Porcine Lactate Dehydrogenase research:
BABAB elementary supersecondary structure of the Rossmann fold from porcine lactate dehydrogenase exhibits characteristics of a molten globule. Lactate Dehydrogenase LDH REF:Proteins: Structure, Function, and Bioinformatics Volume 60,Issue 4 ,Pages 740-745
Animal Lactate Dehydrogenase LD,LDH research: Structural Adaptations of Lactate Dehydrogenase Isozymes. lactate Dehydrogenase ldh ld REF: PNAS July 1, 1977 vol. 74 no. 7 2677-2681/ldh/lactate/dehydrogenase.
Lactate Dehydrogenase LD,LDH research: An Eimeria vaccine candidate appears to be lactate dehydrogenase; characterization and comparative analysis. LDH lacate Dehydrogenase REF: Parasitology (2004), 128: 603-616 Cambridge University Press/ld/ldh/dehydrogenase
Lactate Dehydrogenase LD,LDH research:Evolutionary Relationships of Lactate Dehydrogenases (LDHs) from Mammals, Birds, an Amphibian, Fish, Barley, and Bacteria: LDH cDNA Sequences from Xenopus, Pig, and Rat. lacate Dehydrogenase LDH REF: Proceedings of the National Academy of Sciences, Vol 91, 9392-9396 1994/ld/ldh/dehydrogenase.
Lactate Dehydrogenase LD,LDH research:Partial and delayed release of troponin-I compared with the release of lactate dehydrogenase from necrotic cardiomyocytes. lacate Dehydrogenase LDH REF:Pflügers Archiv European Journal of Physiology Volume 448,Number 2,May,2004/ldh/lacate/dehydrogenase.
Human Lactate Dehydrogenase article: Effect of selected alcohol dehydrogenase inhibitors on the human heart lactate dehydrogenase activity.Human Lactate Dehydrogenase REF: Acta Physiologica Hungarica Volume 91, Numbers 3-4, November 2004/ldh/ld/lactate dehydrogenase
Human Lactate Dehydrogenase research: Lactate dehydrogenase and its isoenzyme activities in different parts of the normal human heart. Human Lactate Dehydrogenase REF: Cardiovasc Res. 1989 Jul;23(7):601-6/ldh/ld/lactate dehydrogenase
Lactate Dehydrogenase isoenzyme research: Lactate dehydrogenase isoenzyme patterns upon chronic exposure to cigarette smoke: Protective effect of bacoside. Lactate Dehydrogenase LDH isoenzyme REF: Environmental Toxicology and Pharmacology Vol. 20, No. 2, pages 345-350 (2005)/ldh/ld/lactate dehydrogenase
Human Lactate dehydrogenase LDH isoenzyme article: Isoenzyme profile of lactate dehydrogenase in the cranial cervical sympathetic ganglion under normal conditions and during synaptic blockade.Lactate Dehydrogenase LDH isoenzyme REF: Bulletin of Experimental Biology and Medicine Volume 140, Number 6 December, 2005/ldh/ld/lactate dehydrogenase
Human Lactate Dehydrogenase research:Quantification of Viability in Organotypic Multicellular Spheroids of Human Malignant Glioma using Lactate Dehydrogenase Activity. Lactate Dehydrogenase LDH REF: Journal of Histochemistry and Cytochemistry Volume 53 (1): 23-34, 2005/ldh/ld/lactate dehydrogenase
Human Lactate Dehydrogenase article: Expression of vascular endothelial growth factor, fibroblast growth factor, and lactate dehydrogenase by human peritoneal mesothelial cells in solutions with lactate or bicarbonate or both. Lactate Dehydrogenase LDH REF: Adv Perit Dial. 2006;22:37-40/ldh/ld/lactate dehydrogenase
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