Item#: 431-11R Myoglobin Human ( recombinant )
Product Info:
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| Product Name: | Myoglobin Human ( recombinant ) |
|---|---|
| Cat. No: | 431-11R |
| Form: | Liquid. Bufferized solution (pH 7.4): |
| Molecular Weight: | 17.5 kd |
| Protein Conc:: | Typically > 1mg/ml |
| Purity: | Single major band visualized |
| Source: | Recombinant |
| Storage: | -20C |
| Synonyms: | rMb, h-rMb, r-Myoglobin |
RECOMBINANT HUMAN MYOGLOBIN bulk quantities greater than 100mgs single lot sizes available. Custom fills for recombinant human myoglobin available.
Description: Human recombinant Myoglobin (Mb) is a cytosolic protein comprising 153 amino acid residues, found in skeletal and cardiac muscle but not in smooth muscle. It has been well known that Human recombinant Myoglobin (Mb) functions as an oxygen transporter capable of reversible oxygenation and deoxygenation.
Human recombinant Myoglobin (Mb): recombinant human myoglobin is assembled in E.coli as holo-form, which combines iron-porphyrin (heme) group during expressing the gene coding apo-protein in human heart muscle.
Myoglobin related products that we offer:
431-11R Recombinant Human Myoglobin
431-11 Native Human Myoglobin
CMY-80A Polyclonal chicken anti-myoglobin affinity purified
SMY-80A Polyclonal sheep anti-human myoglobin affinity purified
Human recombinant Myoglobin (Mb)Applications: Standard for ELISA ,
Standard for immunoblotting, High qualified antigen for antibody production
HUMAN MYOGLOBIN:
Human Myoglobin is a single-chain globular protein of 153 amino acids. Myoglobin contains a heme (iron-containing porphyrin) prosthetic group in the center around which the remaining apoprotein folds. Human Myoglobin has a molecular weight of 16,700 daltons. Human Myoglobin is found in skeletal and cardiac muscle cells and is capable of reversibly binding molecular oxygen and enhancing the rate of oxygen diffusion through the muscle cell. Human Myoglobin is an oxygen carrier in the cytoplasm and appears to be responsible for the transport of oxygen from the cell membrane to the mitochondrion.
Human cardiac Myoglobin (Mb) is a Haem containing protein and implicated as a cause of acute renal failure following damage to muscle tissue (e.g. rhabdomyolysis, severe crush trauma, malignant hyperthermia, status epilepticus and neuroleptic malignant syndrome), due to its toxicity to renal tubular epithelium. Human Myoglobin also serves as a useful biomarker for the detection of successful reperfusion following thrombolytic therapy.
Human Myoglobin Research: Human Myoglobin(Mb) shares limitations to biomarkers such as Human Troponin and Human CK due to high concentrations in skeletal muscle, Human Myoglobin(s) small molecular size and consequent rapid rise in the setting of myocardial necrosis. Human Myoglobin REF: The National Academy of Clinical Biochemistry indicates Human Myoglobin(Mb) has retained a value of a very early marker of MI (Myocaridal Infarction).
Human myoglobin Clinical studies have shown that the combined use of myoglobin and a more specific marker of myocardial necrosis (cardiac troponin or isoenzyme CK-MB) may be useful for early exluclusion of MI.
Human Heart Myoglobin Research: The case of myoglobin-facilitated oxygen diffusion.Human Heart Myoglobin REF:
Gene, 25 April 2007, Jonathan B. Wittenberg/human/myoglobin/cardiac.
Human Myogloin study: Expression of human myoglobin in H9c2 cells enhances toxicity to added hydrogen peroxide. Human Myoglobin Ref: Biochemical and Biophysical Research Communications, Volume 348, Issue 2, 22 September 2006, Pages 485-493/human/myoglobin/cardiac.
Human heart myoglobin study: Human myoglobin recognition of oxygen: Dynamics of the energy landscape. Human Myoglobin REF: PNAS,December 28, 2004 vol. 101, no. 52/human/myoglobin/cardiac.
Human heart Myoglobin Research: Utilization of myoglobin as a heme source by Haemophilus influenzae requires binding of myoglobin to haptoglobin. Human heart Myoglobin REF: FEMS Microbiology Letters Volume 258 Issue 2 Page 235 - May 2006/human/myoglobin/cardiac.
Human heart myoglobin study: Emerging Roles for Human Myoglobin in the Heart. Human Myoglobin (Mb) is an intensely studied hemoprotein that is restricted mainly to the heart and oxidative myofibers in skeletal muscle. Human heart Myoglobin REF: Trends in Cardiovascular Medicine Volume 13, Issue 3, April 2003, Pages 111-116/human/myoglobin/cardiac.
Human heart Myoglobin research: Diagnostic utility of new immunoassays for the cardiac markers cTnI, myoglobin and CK-MB mass. human myoglobin REF: Clinical Biochemistry, Volume 38, Issue 11, November 2005, Pages 1027-1030/human/myoglobin/cardiac.
Human heart Myoglobin Research: Myoglobin concentration and succinate dehydrogenase activity in skeletal muscle and age determine VO2max of chronic heart failure patients. Human Myoglobin REF: European Journal of Heart Failure Supplements, Volume 4, Issue 1, June 2005, Page 118/human/myoglobin.
Human Heart Myoglobin Research: Clinical significance of myoglobin and troponin-T in short-lasting severe myocardial ischemia. Human Myoglobin REF: International Journal of Cardiology, Volume 98, Issue 2, 15 February 2005, Pages 285-290/human/myoglobin.
Human Heart Myoglobin Research: Effects of contemporary troponin assay sensitivity on the utility of the early markers myoglobin and CKMB isoforms in evaluating patients with possible acute myocardial infarction.Human Heart Myoglobin Ref: Clinica Chimica Acta, Volume 380, Issues 1-2, 1 May 2007, Pages 213-216/human/myoglobin.
Human Heart Myoglobin Research: The Impact of B-Type Natriuretic Peptide in Addition to Troponin I, Creatine Kinase-MB, and Myoglobin on the Risk Stratification of Emergency Department Chest Pain Patients With Potential Acute Coronary Syndrome.Human Heart Myoglobin Ref: Annals of Emergency Medicine, Volume 49, Issue 2, February 2007, Pages 153-163/human/myoglobin.
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