We Are Solutions...On Demand
We Are Solutions...On Demand
Item #: 342-41
Activity:
> 100 units/ml
Cat. No:
342-41
Expiration:
1 year before retest
UNSPSC code:
51131907
Form:
0.2 micron filtered solution in 0.05 M sodium acetate, 0.6 M sodium chloride, pH 5.5
Product Name:
NEUTROPHIL ELASTASE
CAS No:
9004-06-2
Purity:
> 98 % Pure by SDS Page
EC No:
3.4.21.37
Protein Conc::
Typically > 2mgs/ml
Storage:
2-8C
Synonyms:
ELA-2, Elastase, hne
Highly Purified HUMAN NEUTROPHIL ELASTASE ANTIGEN GRADE. Highest Purity Available.
Identity confirmed by Western blotting for Neutrophil Elastase
Definition: One unit will hydrolyze one micromole of methoxy succinyl-alanine-alanine-proline-valine-p-nitroanilide per minute at 37C and pH 7.5.
Elevation of NE levels/activity has been demonstrated in a variety of pathological conditions including cystic fibrosis , acute respiratory distress syndrome, bronchiectasis, chronic obstructive pulmonary disease, type2 diabetes mellitus, atherosclerosis, aortic stiffness and systolic hypertension according to current studies.
Neutrophil elastase (NE) is a key enzyme for tissue injury caused by activated neutrophils, such as occurs in Acute Lung injury.
Neutrophil Elastase Is Produced by Pulmonary Artery Smooth Muscle Cells and Is Linked to Neointimal Lesions according to Department of Pediatrics and the Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, California.
Lee Biosolutions, Inc specializes in the development and purification of high quality BioMarkers for the Immunodiagnostic, clinical diagnostic and pharmaceutical industry worldwide.
