Item#: 129-15 NT-ProBNP, (Recombinant)

N-terminal pro-B-type natriuretic peptide NT-proBNP: Tests showing elevated levels of BNP or NT-proBNP in the blood are used as a diagnosis of heart failure and may be useful to establish prognosis in heart failure, as both markers are typically higher in patients with worse outcome.

Both BNP and N-terminal pro-B-type natriuretic peptide NT-proBNP have been approved as a marker for acute congestive heart failure (CHF). The plasma concentrations of both BNP are increased in patients with asymptomatic and symptomatic left ventricular dysfunction.

N-terminal pro-B-type natriuretic peptide NT-ProBNP: Many studies have demonstrated the clinical utility of measuring plasma concentrations of NP(s), including NT-proBNP. NP(s) have been suggested as the biomarkers of choice for diagnosis and risk stratification of patients with heart failure NT ProBNP REF: (Boomsma et al. Cardiovascular Research 51:442-449 2001/nt/probnp/bnp

NPs have been shown to have good prognostic value with regards to both morbidity and mortality in heart failure. Several studies have also demonstrated the utility of NP measurements in the prediction of left ventricular dysfunction and survival following acute myocardial infarction NT ProBNP REF:Richards et al. Circulation 97:1921-1929 1998/nt/probnp/bnp