Polyclonal Antibody: anti-human alpha-1-antitrypsin A1AT procedure: Chickens were immunized using purified human alpha-1-anti trypsin as the immunogen. To ensure specificity the resulting antiserum was solid phase absorbed and affinity purified off an antigen containing immunoabsorbant.
This product is specific for alpha-1-antitrypsin by ELSIA, immunodiffusion and IEP analysis. No reaction with other human proteins is observed
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Human alpha 1 Antitrypsin or Human A1-antitrypsin (A1AT), also known as serum trypsin inhibitor. Human alpha-1 Antitrypsin (A1AT) is a serine protease inhibitor (serpin) and trypsin inhibitor.
Human alpha 1 Antitrypsin (A1AT) protects tissue from enzymes from inflammatory cells, especially elastase and is present in human blood.
Disorders of the enzyme include HUman alpha-1 antitrypsin deficiency, a hereditary disorder in which lack of Human alpha-1 Antitrypsin AAT(A1AT)leads to uninhibited tissue breakdown during inflammation. Studies indicate that this causes pulmonary emphysema and leads to liver cirrhosis in severe cases.