We Are Solutions...On Demand
We Are Solutions...On Demand
Item #: 497-50
Source:
Human Neutrophils
Cat. No:
497-50
Storage:
Below -20 C Long Term
Protein:
Typically >0.5 mg protein/mL by BCA
Form:
Solution in 0.05 M sodium acetate, 0.7 M sodium chloride , pH 6.0
Purity:
> 96% by SDS-PAGE, Identity confirmed by Western Blot
Expiration:
1 year
Synonyms:
PR3 Ag, PR3, PR III, Myoblastin
Lee Biosolutions producer of Proteinase 3 provides in small research and bulk quantiteis. As a manufacture of high purity human proteins Lee Biosolution is able to custom fill and provide a buffer of your choice for Proteinase 3-PR3.
Current Research suggests that PR3 may represent a clinically useful marker of prognosis after an AMI as part of a multimarker strategy. Proteinase 3 is the major target antigen of antineutrophil cytoplasmic autoantibodies (ANCA) in Wegener's granulomatosis and is contained in the azurophilic granules of polymorphonuclear neutrophils, the dominant cell type in vascular lesions during the early stages of systemic vasculitis.
LeeBio's HUMAN PROTEINASE 3(PR3)from human neutrophils is available in bulk quantities. Human Proteinase 3(PR3) custom buffers available. Human Proteinase 3(Human PR3) protein custom fills available
Human (PR3)Proteinase 3 : Unit Definition: One unit will hydrolize one micromole of Methoxy succinyl-alanine-alanine-proline-valine-p-nitroanilide per minute at 37C and pH 7.5
Human Proteinase 3(Human PR3)is a serine protease enzyme expressed mainly in neutrophil granulocytes. Human Proteinase 3(PR3) exact role in the function of the neutrophil is unknown. Proteinase 3(PR3) is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
Lee Biosolutions, Inc specializes in the development and purification of high quality BioMarkers for the Immunodiagnostic, clinical diagnostic and pharmaceutical industry worldwide.
