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Item #: 494-10
Lead Time Required
Typically >1.0 mg/mL
1H-Pyrrole-3-propanoic acid, 5-(aminomethyl)-4-(carboxymethyl)-
>95% pure by SDS-PAGE
20 mM Tris-HCl
Lee Biosolutions PORCINE PROTHROMBIN available in bulk quantities from 50-500 mg. Custom fills of porcine prothrombin available.
Prothrombin is a blood-clotting protein. Injury to a blood vessel produces a signal which triggers the conversion of prothrombin to thrombin. Thrombin is a protein which plays a central role in provoking the assembly of other proteins to form the blood clot.
Prothrombin Consumption Test:
determines thromboplastin generating capacity, which provides information about the first stage of coagulation. When clotting of a normal blood sample occurs, prothrombin is converted to thrombin, thus there should be little or no prothrombin in the serum after the clot is formed. If, however, there is deficiency of blood coagulation, some of the prothrombin will not be utilized (consumed). Abnormal results of the test are found in deficiencies of the first-stage factors of coagulation (factors VIII and IX), and in the presence of circulating anticoagulants, thrombocytopenia, and any other condition leading to inadequate generation of thromboplastin. Called also serum clot time