We Are Solutions...On Demand
We Are Solutions...On Demand
Item #: 125-20
Storage:
-20C, Avoid repeat freeze thaw cycles
Cat. No:
125-20
UNSPSC code:
51131909
Molecular Weight:
34-37 kDa
Source:
Human Plasma
Protein Conc::
Typically 1mg/ml
Form:
75mM PBS, 75 mM NaCL, .5 EDTA, pH 7.4
Purity:
> 98% pure by SDS PAGE
HUMAN APOE APOLIPOPROTEIN E (APOE)bulk quantities from 10-100mgs quantities. Custom fills for Human Apolipoprotein E (APOE) available.
High Purity Human Apolipoprotein E (APOE), is purified from delipidated VLDL. Minor impurities removed by affinity chromotography.
The human Apolipoprotein E (APOE), is 299 amino acids long and transports lipoproteins, fat-soluble vitamins, and cholesterol into the lymph system and then into the blood. Apolipoprotein E (APOE), is synthesized principally in the liver, but has also been found in other tissues such as the brain, kidneys, and spleen. In the nervous system, non-neuronal cell types, most notably astroglia and microglia, are the primary producers of Apolipoprotein E (APOE), while neurons preferentially express the receptors for Apolipoprotein E (APOE).
APOE Lipoprotein,Apo-E is a 34-37 kDa glycosylated protein. Concentration in normal plasma is 5 mg/dl. APOE Lipoprotein,Apo-E is involved with triglyceride, phospholipid, cholesteryl ester, and cholesterol transport in and out of cells and is a ligand for LDL receptors. APOE Lipoprotein, Apo-E has also been implicated in immune and nerve degeneration. APOE Lipoprotein has been found to suppress lymphocyte proliferation. Late-onset familial and sporadic Alzheimer disease patients have been found to have a higher occurrence of one of the three common Apo-E isoforms, Apo-E4. The Apo-E4 isoform has been detected in senile plaques and neurofibrillary tangles of Alzheimer disease patients. Apo-E4 is associated with rapid chylomicron-remnant clearance and increased total cholesterol levels.
Lipoprotein products that we offer:
125-12 Human APO A1 Tissue Culture Grade
125-17 APO A11 Human Apolipoprotein
125-19 APO CI Human Apolipoprotein
125-21 APO CIII Human Apolipoprotein
125-20 APOE Human Apolipoprotein
185-10 Bovine CHOLESTEROL CONCENTRATE
361-10 High Density Lipoprotein(s) Human HDL
Lee Biosolutions, Inc specializes in the development and purification of high quality BioMarkers for the Immunodiagnostic, clinical diagnostic and pharmaceutical industry worldwide.
