Item#: 510-11 RENIN, Human

Highest Purity Native Human Renin on the market today. Extensive Research and chromatography performed to provide RENIN for research and IVD manufacturing. HUMAN NATIVE RENIN ENZYME from human kidney BULK QUANTITIES from 10-100 unit single lot sizes. Custom human Renin purification from other species is also available

Human Renin and Human Prorenin products we offer:
510-11PR Recombinant Human Prorenin Human
510-11 Native Human Renin
510-11R Recombinant Human Renin Human

What is Human Renin?
Human Renin, also known as angiotensinogenase, is a circulating enzyme released mainly by juxtaglomerular cells in the JGA of the kidneys in response to low blood volume or low body NaCl content, mediated through the release of prostaglandins. Although human Renin has hormone-like actions, human Renin cleaves a protein precursor in the circulation rather than working on a cellular target.

Human Renin is an important enzyme in the regulation of blood pressure and electrolyte homeostasis and therefore is of great clinical importance. Kinetic and mechanistic functions of human Renin are of importance for the development of hypertension drugs. Plasma renin activity (PRA) is measured as part of the diagnosis and treatment of hypertension.

Human Renin acts as a proteolytic enzyme of the kidney by releasing angiotensin which has a vasoconstrictive action which results in a higher blood pressure. Early detection of Human renin level increases related to a blood pressure increase have shown in research to provide vital prognostic and diagnostic guidelines for evaluating possible surgical treatment especially in renovascular involvement.