Human Urine RETINOL BINDING PROTEIN (RBP)

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Item #: 525-11

Details

HUMAN RETINOL BINDING PROTEIN (RBP) BULK QUANTITIES from 50-500mg single lot sizes. We are able to purify Human Retinol Binding Protein in the buffer of your choice. Inquire on custom fills of Human Retinol Binding Protein.

Other Binding Proteins available:
276-10 Human Fatty Acid Binding Protein
525-11 Human Retinol Binding Protein
CRBP-80A Retinol Binding Protein, Polyclonal Affinity Purified

Recommended Reconstitution of Human Retinol binding Protein (RBP): Use of a phosphate buffer,pH >7.0 containing 0.15M NaCl

Human Retinol binding protein (RBP) is responsible for binding and transporting retinol (vitamin A).human retinol binding protein (RBP)has a binding site for one molecule of retinol and circulates in the plasma together with prealbumin in the form of a protein complex in a molar ratio of 1:1. This binding to prealbumin prevents greater glomerular losses of the human retinol-binding protein. Only the retinol-free form of the retinol-binding protein,which has no affinity for prealbumin,undergoes glomerular filtration unhindered as a result of its low molecular weight;human retinol binding protein (RBP) is re-absorbed by the tubular cells and catabolized there.

This explains the elevated serum level of human retinol-binding protein in advanced chronic renal insufficiency. Since human retinol-binding protein and human prealbumin are synthesized in the liver, their serum concentrations are reduced in acute and chronic hepatic diseases.Decreased concentrations of Human Retinol binding Protein (RBP)have also been observed in cystic fibrosis.

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