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Item #: 550-13
Source:
Human Skeletal Muscle
Form:
8 M urea, 100 mM NaCl, 50 mM Tris.HCl (pH
Product Name:
TROPONIN I
Storage:
-20 C Recommended
Concentration:
Typically 1mg/ml
Cat. No:
550-13
Human Skeletal Marker Troponin I BULK QUANTITIES from 10-100 mg single lot sizes. Skeletal marker human troponin I custom fills to meet your research requirements. Human Skeletal Marker Troponin is a preferred marker for risk stratification.
Troponin I (TnI) is one of three subunits that form the troponin complex of the thin
filaments of striated muscle. The troponin complex serves as a calcium-sensitive switch
that regulates striated muscle contraction. Troponin I binds actin and inhibits actomyosin
ATPase activity in the absence of calcium. Skeletal muscle troponin I exists in two
isoforms, TnI-fast and TnI-slow, expressed respectively in fast and slow-twitch muscle
fibers. The two isoforms are characterized by molecular weights ~ 21 kDa (fast) and 22
kDa (slow). The ratios of slow and fast isoforms vary with muscle source and species.
Human Troponin is a family of proteins (cardiac troponin I,cardiac troponin T and cardiac troponin C) found in skeletal and heart muscle fibers; cardiac troponin helps muscles contract. Certain subtypes of human troponin (cardiac troponin I and troponin T) are very sensitive and specific indicators of damage to the heart muscle myocardium). Human Troponin(s) are measured in the blood to differentiate between unstable angina and myocardial infarction (heart attack) in patients with chest pain. A patient who had suffered from a myocardial infarction would have an area of damaged heart muscle and so would have elevated cardiac troponin levels in the blood.
Lee Biosolutions, Inc specializes in the development and purification of high quality BioMarkers for the Immunodiagnostic, clinical diagnostic and pharmaceutical industry worldwide.
