Pepsinogen I (PGI, PGA)
|Product Name||Pepsinogen I|
|Source||Human Gastric Mucosa|
|Availability||Discontinued, replaced with item 440-50|
|Purity||> 90% (SDS-PAGE)|
|Identity||Confirmed by Western Blot|
|Protein||> 0.5 mg/mL (A280, E0.1%=1.48)|
|Molecular Weight||45 kDa|
|Synonyms||Pepsinogen A, PG1, PGA|
Lee Biosolutions is the leading producer and supplier of human gastric Pepsinogen I (A) antigen as a cancer marker for medical research, clinical and biomedical manufacturing.
Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
Human Pepsinogens are aspartic proteases produced in the gastric mucosa and secreted into the gastric lumen that play a major role in the digestion of proteins after activation of acidic pH. It is synthesized as isoymogens and are classified into two groups, Pepsinogen I and Pepsinogen II).
Human PGA and PGC antigen have been investigated as a possible biomarker for early detection of, Gastric cancer (GC), adenoma (GA) and severe atrophic (diffuse or patchy) corpus gastritis.
It has been reported that human Pepsinogen I (PGA)levels were lower in atrophic corpus gastritis than in atrophic antral gastritis, and human pepsinogen I(PGA) levels were lower in advanced gastric cancer than early stage gastric cancer.