Proteinase 3 (PR3) - ANCA
|Product Name||Proteinase 3|
|Purity||> 96% (SDS-PAGE)|
|Purity Note||Identity confirmed by Western Blot|
|Protein||0.1 - 1.5 mg/mL (BCA)|
|Activity||Typically > 0.1 U/mg protein|
|Unit Definition||One unit will hydrolize one micromole of Methoxy succinyl-alanine-alanine-proline-valine-p-nitroanilide per minute at 37°C and pH 7.5.|
|Form||Solution in 0.05 M sodium acetate, 0.7 M sodium chloride|
|Synonyms||Myeloblastin, AGP7, C-ANCA antigen, Leukocyte proteinase 3, PR-3, PR3, Neutrophil proteinase 4, NP-4, P29, Wegener autoantigen|
Lee Biosolutions is the leading supplier of Human Proteinase 3 (PR-3) for research and diagnostic manufacturing.
Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
Current Research suggests that PR3 may represent a clinically useful marker of prognosis after an AMI as part of a multimarker strategy. It is the major target antigen of antineutrophil cytoplasmic autoantibodies (ANCA) in Wegener's granulomatosis and is contained in the azurophilic granules of polymorphonuclear neutrophils, the dominant cell type in vascular lesions during the early stages of systemic vasculitis.