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Proteinase 3 (PR3) - ANCA


Product Name Proteinase 3
Source Human Neutrophils
Catalogue Number 497-50
Purity > 96% (SDS-PAGE)
Purity Note Identity confirmed by Western Blot
Form Liquid
Protein 0.1 - 1.5 mg/mL (BCA)
Activity Typically > 0.1 U/mg protein
Unit Definition One unit will hydrolize one micromole of Methoxy succinyl-alanine-alanine-proline-valine-p-nitroanilide per minute at 37°C and pH 7.5.
Recertification 2 years
Storage -20°C
Form Solution in 0.05 M sodium acetate, 0.7 M sodium chloride
Synonyms Myeloblastin, AGP7, C-ANCA antigen, Leukocyte proteinase 3, PR-3, PR3, Neutrophil proteinase 4, NP-4, P29, Wegener autoantigen
CAS Number 128028-50-2
E.C. Number
Gene ID 5657
Accession No P24158
497-50 $ 895.00 25 ug
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Lee Biosolutions is the leading supplier of Human Proteinase 3 (PR-3) for research and diagnostic manufacturing.

Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.

Current Research suggests that PR3 may represent a clinically useful marker of prognosis after an AMI as part of a multimarker strategy. It is the major target antigen of antineutrophil cytoplasmic autoantibodies (ANCA) in Wegener's granulomatosis and is contained in the azurophilic granules of polymorphonuclear neutrophils, the dominant cell type in vascular lesions during the early stages of systemic vasculitis.

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Testing/Assay Validation

Life Science

ELISA, Blotting, Etc.