Item#: 106-11 ALPHA-1 ANTITRYPSIN (A1AT ) Human
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| Product Name: | ALPHA-1 ANTITRYPSIN (A1AT ) Human |
|---|---|
| Cat. No: | 106-11 |
| Expiration: | 1 year |
| Form: | Lyophilized |
| Molecular Weight: | 54kDa |
| Protein: | Typically >1 mg/ml dispensing solution |
| Purity: | >95% by SDS-Polyacrylamide Gel |
| Source: | Human Plasma |
| Storage: | 2-8 C |
| Synonyms: | A1AT, Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) |
| UNSPSC code: | 51131904 |
HUMAN ALPHA-1 ANTITRYPSIN (A1AT ) AAT BULK QUANTITIES from 10 mg to 2000 mg single lot sizes. Inquire on purifying human alpha-1 antitrypsin AAT(A1AT) in the buffer of your choice on bulk orders. Custom fills for human alpha-1 antitrypsin available.
Recommended dispensing solution for Human alpha-1 Antitrypsin (A1AT): 0.05M phosphate buffer pH >7.0 containing 0.15M NaCl
Human alpha-1 antitrypsin also known as a1-Antitrypsin, Human (AAT, alpha-1-AT, alpha1 Proteinase Inhibitor, alpha1 PI
Human alpha 1 Antitrypsin or Human A1-antitrypsin (A1AT), also known as serum trypsin inhibitor. Human alpha-1 Antitrypsin (A1AT) is a serine protease inhibitor (serpin) and trypsin inhibitor.
Human alpha 1 Antitrypsin (A1AT) protects tissue from enzymes from inflammatory cells, especially elastase and is present in human blood.
Disorders of the enzyme include HUman alpha-1 antitrypsin deficiency, a hereditary disorder in which lack of Human alpha-1 Antitrypsin AAT(A1AT)leads to uninhibited tissue breakdown during inflammation. Studies indicate that this causes pulmonary emphysema and leads to liver cirrhosis in severe cases.
Human alpha-1 antitrypsin protects the lungs from the harmful effects of human neutrophil elastase
The protein is called "antitrypsin" because of its ability to covalently bind and irreversibly inactivate the enzyme trypsin
Available Polyclonal antibody affinity purified Goat anti-Human Alpha-1-Antitrypsin CAT. NO: GAIT-80A
Human alpha-1 Antitrypsin (A1AT) STUDY: alpha 1 Antitrypsin AAT(A1AT)is synthesised in the liver and protects lung alveolar tissues from destruction by neutrophil elastase.
alpha-1 Antitrypsin AAT(A1AT)deficiency is a common autosomal recessive condition in which liver disease results from retention of abnormal polymerised alpha-1 Antitrypsin AAT(A1AT)in the endoplasmic reticulum of hepatocytes. The clinical consequences of alpha 1-Antitrypsin (A1AT)deficiency in childhood are haemorrhagic disease in infancy, cholestasis in infancy, or chronic liver disease.
Human alpha-1 Antitrypsin (A1AT) STUDY: Lung disease attributable to alpha 1 Antitrypsin (A1AT)deficiency does not occur in childhood, but is closely linked to smoking in adults. Membranoproliferative glomerulonephritis, panniculitis, and necrotising vasculitis are associations with alpha 1 Antitrypsin (A1AT)deficiency in adult life.REF: Arch Dis Child 2001;85:2-5 ( July )/antitrypsin
Human Alpha 1 antitrypsin (AAT) consisting of a single polypeptide chain and has a molecular weight of 54kD. Human Alpha-1 antitrypsin (AAT) exists in a number of genetic variants. MM variant is the most common. Human Human Alpha-1 antitrypsin (AAT) is synthesized in the liver and Human Alpha-1 antitrypsin (AAT) acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha 1-Antitrypsin AAT, these enzymes are not inhibited and they may digest pulmonary parenchyma. alpha-1 Antitrypsin AAT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn.
Increase in human alpha-1 Antitrypsin AAT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT AAT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis. In colorectal and lung carcinomas, alpha-1 Antitrypsin AAT has also related to their invasive and metastatic capacity. An alpha-1 antitrypsin AAT concentration is ordered to help diagnose the cause of early onset emphysema.
Human alpha-1 Antitrypsin (A1AT) STUDY: Alpha-1 antitrypsin AAT(A1AT)is ordered to help diagnose the cause of persistent jaundice and other signs of liver dysfunction. REF: labtest online/antitrypsin/human/alpha-1
Human alpha-1 Antitrypsin (A1AT) STUDY: a1-Antitrypsin(human alpha-1 antitrypsin) Precursor in Gastric Juice Is a Novel Biomarker for Gastric Cancer and Ulcer. Human alpha-1 Antitrypsin (A1AT) REF: Clinical Cancer Research 13, 876-883, February 1, 2007/antitrypsin/human/alpha/1
Human alpha-1 Antitrypsin (A1AT) STUDY: Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: A meeting review.. Human alpha-1 Antitrypsin (A1AT) REF:Hepatology. 2007 May;45(5):1313-23./antitrypsin/human/alpha
Human alpha-1 Antitrypsin (A1AT) STUDY: Human Alpha 1 Antitrypsin Protects {beta}-Cells from Apoptosis. Human alpha-1 Antitrypsin (A1AT) STUDY: REF: Diabetes. 2007 Mar 14/antitrypsin/human/alpha
Human alpha-1 Antitrypsin (A1AT) STUDY: Diagnosis of a-1-Antitrypsin Deficiency: An Algorithm of Quantification, Genotyping, and Phenotyping.Human alpha-1 Antitrypsin (A1AT) ref: Clin. Chem., Dec 2006; 52: 2236 - 2242/human/alpha/anti/trypsin
Human alpha-1 Antitrypsin (A1AT) STUDY: Heterozygous M3Mmalton 1-Antitrypsin Deficiency Associated with End-Stage Liver Disease: Case Report and Review.Human alpha-1 Antitrypsin (A1AT) ref:Clin. Chem., Aug 2001; 47: 1490 - 1496/antitrypsin/human/alpha/trypsin/a1at
Human alpha-1 Antitrypsin (A1AT) STUDY: Does Genetic Testing Result in Behavioral Health Change? Changes in Smoking Behavior
Following Testing for Alpha-1 Antitrypsin Deficiency .Human alpha-1 Antitrypsin (A1AT).Ann Behav Med 2007, 33(1):22–28/ alpha-1 Antitrypsin (A1AT)
Human alpha-1 Antitrypsin (A1AT) STUDY:Determinants of Airflow Obstruction in Severe Alpha 1- Antitrypsin Deficiency.Human alpha-1 Antitrypsin (A1AT).Thorax. Published Online First: 27 March 2007. doi:10.1136/thx.2006.075846
Copyright © 2007 BMJ Publishing Group Ltd & British Thoracic Society
key word: human alpha-1 antitrypsin protein, human alpha-1 antitrypsin assay,human alpha 1 antrypsin research