Item#: 125-20 APOLIPOPROTEIN E Human
Product Info:
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| Product Name: | APOLIPOPROTEIN E Human |
|---|---|
| Cat. No: | 125-20 |
| Form: | 75mM PBS, 75 mM NaCL, .5 EDTA, pH 7.4 |
| Molecular Weight: | 34-37 kDa |
| Protein Conc:: | Typically 1mg/ml |
| Purity: | > 98% pure by SDS PAGE |
| Source: | Human Plasma |
| Storage: | -20C, avoid repeat freeze thaw cycles |
| UNSPSC code: | 51131909 |
HUMAN APOE APOLIPOPROTEIN E(APOE)bulk quantities from 10-100mgs quantities. Custom fills for Human Apolipoprotein E (APOE) available.
High Purity Human Apolipoprotein E (APOE), is purified from delipidated VLDL. Minor impurities removed by affinity chromotography
The human Apolipoprotein E (APOE), is 299 amino acids long and transports lipoproteins, fat-soluble vitamins, and cholesterol into the lymph system and then into the blood. Apolipoprotein E (APOE), is synthesized principally in the liver, but has also been found in other tissues such as the brain, kidneys, and spleen. In the nervous system, non-neuronal cell types, most notably astroglia and microglia, are the primary producers of Apolipoprotein E (APOE), while neurons preferentially express the receptors for Apolipoprotein E (APOE)
APOE Lipoprotein,Apo-E is a 34-37 kDa glycosylated protein. Concentration in normal plasma is 5 mg/dl. APOE Lipoprotein,Apo-E is involved with triglyceride, phospholipid, cholesteryl ester, and cholesterol transport in and out of cells and is a ligand for LDL receptors. APOE Lipoprotein, Apo-E has also been implicated in immune and nerve degeneration. APOE Lipoprotein has been found to suppress lymphocyte proliferation. Late-onset familial and sporadic Alzheimer disease patients have been found to have a higher occurrence of one of the three common Apo-E isoforms, Apo-E4. The Apo-E4 isoform has been detected in senile plaques and neurofibrillary tangles of Alzheimer disease patients. Apo-E4 is associated with rapid chylomicron-remnant clearance and increased total cholesterol levels
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Human Apolipoprotein E (APOE) Research: pathway-dependent on apoE, ApoAI, and ABCA1 determines formation of buoyant high-density lipoprotein by macrophage foam cells. Human Apolipoprotein E (APOE) REF: Arterioscler Thromb Vasc Biol. 2007 May;27(5):1123-31. Epub 2007 Feb 15/lipoprotein/APOLIPOPROTEIN E(APOE)
Human Apolipoprotein E (APOE) Research:Polymorphism of apolipoprotein E (APOE) and lipoprotein lipase (LPL) genes and ischaemic stroke in individuals of Yakut ethnicity. Human Apolipoprotein E (APOE) REF: J Neurol Sci. 2007 Apr 15;255(1-2):42-9/lipoprotein/APOLIPOPROTEIN E(APOE)
Human Apolipoprotein E (APOE)Research:The impact of EPA and DHA on blood lipids and lipoprotein metabolism: influence of apoE genotype. Human Apolipoprotein E (APOE) REF: Proceedings of the Nutrition Society (2007), 66: 60-68 Cambridge University Press/lipoprotein/APOLIPOPROTEIN E(APOE)
Human Apolipoprotein E (APOE) Research:Macrophage Low-Density Lipoprotein Receptor-Related Protein Deficiency Enhances Atherosclerosis in ApoE/LDLR Double Knockout Mice. Human Apolipoprotein E (APOE) REF: Arteriosclerosis, Thrombosis, and Vascular Biology.2006 6:2710/HUMAN/APOLIPOPROTEIN E(APOE)
ApoE gene delivery inhibits severe hypercholesterolemia in newborn ApoE-KO mice
Biochemical and Biophysical Research Communications, Volume 361, Issue 2, 21 September 2007, Pages 543-548/APOLIPOPROTEIN E
apolipoprotein A-I research:Altered hepatic lipid status and apolipoprotein A-I metabolism in mice lacking phospholipid transfer protein.apolipoprotein A-I ref:
Atherosclerosis, Volume 190, Issue 1, January 2007/apolipoprotein/a1
apolipoprotein research: Slower speed-of-processing of cognitive tasks is associated with presence of the apolipoprotein ε4 allele.apolipoprotein ref: Journal of Psychiatric Research, Volume 42, Issue 3, February 2008, Pages 199-204/apolipoprotein
apolipoprotein research: Apolipoprotein E isoform-specific binding to the low-density lipoprotein receptor.apolipoprotein ref:
Analytical Biochemistry, Volume 372, Issue 2, 15 January 2008, Pages 222-226/apolipoprotein
apolipoprotein research: Phospholipid Interaction Induces Molecular-level Polymorphism in Apolipoprotein C-II Amyloid Fibrils via Alternative Assembly Pathways.apolipoprotein ref:
Journal of Molecular Biology, Volume 375, Issue 1, 4 January 2008, Pages 240-256/apolipoprotein
apolipoprotein research: Apolipoprotein C1 and Apolipoprotein E Are Differentially Expressed in Atheroma of the Carotid and Femoral Artery.
Journal of Surgical Research, Vol apolipoprotein research: ume 144, Issue 1, January 2008, Pages 132-137/apolipoprotein
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