Item#: 125-10 APROTININ Bovine
Product Info:
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| Product Name: | APROTININ Bovine |
|---|---|
| CAS No: | 9087-70-1 |
| Cat. No: | 125-10 |
| Expiration: | 2 years |
| Form: | Lyophilized |
| Molecular Weight: | 6511.44 |
| Protein: | Typically >0.75 mg/mg |
| Purity: | >95% by Native PAGE |
| Source: | Bovine Lung |
| Storage: | -20 C |
BOVINE LUNG APROTININ BULK QUANTITIES up to 500 gram single lot sizes. Custom fills of bovine lung aprotinin available. Custom buffers available on bovine lung Aprotinin on bulk orders. Cat. NO: 125-10 Bovine Aprotinin is diagnostic grade material.
APROTININ CONTENT: aprotinin Typically >5500 ku/mg (Kallikrein Inactivator Units)/mg
Aprotinin from bovine lung can be used for the isolation of proteins as well as for biopharmaceutical downstream purification to inhibit undesired proteolytic activity of serine proteases such as trypsin, plasmin, trypsinogen, urokinase, chymotrypsin, kallikrein, elastase and others.
Aprotinin from bovine lung can also be used during immunodiffusion, radioimmunoassay or enzyme-linked immuno assay procedures. Aprotinin is used in chromogenic assays for the determination of antithrombin III, heparin, a2-macroglobulin, factor Xa and thrombin to inhibit disturbing kallikrein or plasmin activities
The stability of the Aprotinin molecule is due to the 3 disulfide bonds linking the 6 cysteine members of the chain (Cys5-Cys55, Cys14-Cys38 and Cys30-Cys51). The lysine (15)-alanine (16) sequence on this strongly basic polypeptide represents the active center.
What is Bovine Aprotinin:
A single chain polypeptide isolated from bovine lung with antifibrinolytic and anti-inflammatory activities. As a broad-spectrum serine protease inhibitor, aprotinin bovine competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases, resulting in attenuation of the systemic inflammatory response (SIR), fibrinolysis, and thrombin generation. This agent also inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. Bovine Aprotinin REF: National Cancer Society/bovine/aprotinin.
bovine Aprotinin research: Aprotinin Reduces Cardiac Troponin I Release and Inhibits Apoptosis of olymorphonuclear Cells During Off-Pump Coronary Artery Bypass Surgery.bovine Aprotinin REF: Journal of Cardiothoracic and Vascular Anesthesia, 5 April 2007/bovine/aprotinin.
bovine Aprotinin research: Aprotinin attenuates the inflammatory response in human coronary endothelial cells induced by distinct mechanisms
Journal of Molecular and Cellular. bovine Aprotinin REF: Cardiology, 12 March 2007/bovine/aprotinin.
bovine Aprotinin research: Aprotinin Reduces Troponin I Levels in OPCABG. bovine Aprotinin REF:The Annals of Thoracic Surgery, Volume 82, Issue 5, November 2006, Pages 1950-1951/bovine/aprotinin.
bovine Aprotinin research: Aprotinin improves cerebral protection: Evidence from a survival porcine model. bovine Aprotinin REF: The Journal of Thoracic and Cardiovascular Surgery, Volume 132, Issue 4, October 2006, Pages 948-953/bovine/aprotinin.
bovine Aprotinin research:Aprotinin binding to amyloid fibrils.bovine Aprotinin ref:European Journal of Biochemistry Volume 267 Issue 8 Page 2307 - April 2000/bovine/aprotinin.
bovine Aprotinin research:The effect of aprotinin on transfusion requirements in pediatric orthotopic liver transplantation.bovine Aprotinin ref:Pediatric Transplantation Vol. 7 Issue 2 Page 142 April 2003/bovine/aprotinin.
Aprotinin Research: Effects of surfactants or aprotinin on antithrombin III assay.Aprotinin Reference: Clin. Chem., Mar 1987; 33: 441/bovine/aprotinin.
Bovine Aprotinin Research: Potential Interferences from Blood Collection Tubes in Mass Spectrometric Analyses of Serum Polypeptides.Some types of tubes designed to reduce protein degradation may contain aprotinin. bovine aprotinin Reference: Clinical Chemistry. 2004;50:2398-2401/bovine/aprotinin
Aprotinin research:Effect of recombinant aprotinin on postoperative blood loss and coronary vascular function in a canine model of cardiopulmonary bypass. Aprotinin ref:
European Journal of Cardio-Thoracic Surgery, Volume 32, Issue 2, August 2007, Pages 340-345/aprotinin
aprotinin research: Systemic allergic reactions to aprotinin injection around the Achilles tendon.aprotinin ref:
Journal of Science and Medicine in Sport, Volume 10, Issue 5, October 2007, Pages 320-322/aprotinin
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