Item#: 191-26R2 CK MB Isoenzyme Human Type II ( recombinant )
Product Info:
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| Product Name: | CK MB Isoenzyme Human Type II ( recombinant ) |
|---|---|
| Activity: | Typically >400 u/ml @ 37C |
| Cat. No: | 191-26R2 |
| Expiration: | 1 year |
| Form: | 50% Glycerol, Tris Buffer, pH 6.3-7.2 |
| Protein: | Typically >5 mg/ml |
| Purity: | >90% by capillary electrophoresis |
| Source: | Pichia Pastoris |
| Storage: | -70C |
| Synonyms: | r-hCKMB II, r-hCK-MB, r-hCK-2 |
RECOMBINANT CREATINE KINASE MB isoenzyme, CK-MB Isoenzyme BULK QUANTITIES from 50-500 mg single lot sizes.
Human Creatine Kinase (CPK)CK Unit Definition: One unit will transfer one umole of phosphate from Creatine Phosphate to ADP per minute at 37C. Measured at 340 nm as one equimolar amount of NADH produced by a coupled reaction.
Recombinant full length Creatine Kinase MB Isoenzyme with amino acid sequence exactly the same as the native enzyme. Purified in the enzymatically active form. Reacts with monoclonal antibodies specific to MB isoenzyme in ELISA. CKMB is a 47 kDa dimeric protein comprised of the M and B subunits, produced in Pichia pastoris, and purified under non-denaturing conditions.
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Human isoenzyme creatine kinase MB CKMB, CK-MB (CPK-2) isoenyzme is used due to its ability to detect reinfarction. Human creatine kinase CKMB isoenyzme used to be the gold standard for myocardial necrosis.
Human creatine kinase MB CKMB(CPK-MB)isoenzyme (also called CPK-2 isoenzyme) is found mostly in the heart.
Human creatine kinase CKMB,CK-MB isoenzyme(CPK-2)is one of the most important myocardial markers (in spite of not being altogether cardiac-specific), with well-established roles in confirming acute myocardial infarction (AMI). Human creatine kinase CK-MB CKMB isoenzyme is also used for monitoring reperfusion during thrombolytic therapy following AMI.
Background: Human creatine kinase (CK)CPK isoenzyme(s) are performed when the total Human Creatine phosphokinase (CPK) level is elevated. Isoenzyme testing can help differentiate the source of the damaged tissue. Human Creatine phosphokinase (CPK) CK enzyme consists of two subunits, which can be either B(brain type) or M(muscle type). Three different isoenzymes: Human creatine kinase CKMM(CK-MM) isoenzyme,human creatine kinase CK-BB(CKMM) isoenzyme and human creatine kinase CK-MB(CKMB)isoenzyme exist.
Human (CKBB)CK-BB isoenzyme occurs mainly in brain and lung tissues. Skeletal muscle expresses human (CKMM)CK-MM isoenyzme(98%) and human (CKMB)CK-MB isoenzyme at low levels (1%) in muscle. The myocardium (heart muscle), in contrast, expresses Human (CKMM)CK-MM isoenzyme at 70% and Human CK-MB(CKMB)isoenyme at 30%.
Predominant human Creatine Kinase (CPK)(CK)Expression Human creatine kinase (CK-MM)CKMM isoenyzme in Skeletal Muscle ,human creatine kinase (CK-MB)CKMB isoenzyme in Cardiac Muscle and human creatine kinase (CK-BB)CKBB isoenzyme in Brain and some in lung Tissue
Human creatine kinase CKMB isoenzyme research: COMPARISON OF CKMB,MYOGLOBIN,CK ISOFORM RATIO,HUMAN HEART FATTY ACID-BINDING PROTEIN AND TROPONIN T FOR EARLY DETECTION OF CORONARY REPERFUSION. Human creatine kinaseCKMB REF: Japanese circulation journal Vol.57, No.7(19930720) pp. 659-660/human/isoenyzme(s)/creatine kinase/recombinant
Human creatine kinase CKMB research: Peak CKMB and cTnT accurately estimates myocardial infarct size after reperfusion. Human creatine kinase CKMB REF: Scandinavian Cardiovascular Journal, Volume 41, Issue 1 2007 , pages 44 - 50/human/isoenyzme(s)/creatine kinase/ck/mb/recombinant
Human creatine kinase CKMB research: The behavior of Troponin I and CKMB mass in children who underwent surgical correction of congenital heart malformations. Human creatine kinase CKMB REF: Rev Bras Cir Cardiovasc v.18 n.3 São José do Rio Preto jul.set. 2003/human/isoenyzme(s)/creatine kinase/mb/recombinant
Human creatine kinase CKMB study: Effects of contemporary troponin assay sensitivity on the utility of the early markers myoglobin and CKMB isoforms in evaluating patients with possible acute myocardial infarction. Human creatine kinase CKMB REF: : Clin Chim Acta. 2007 May;380(1-2):213-6. Epub 2007 Jan 23/human/isoenyzme(s)/creatine kinase/mb/recombinant
Human creatine kinase CKMB Study: Diagnostic Efficiency of Creatine Kinase (CK), CKMB, Troponin T and Troponin I in Patients with Suspected Acute Myocardial Infarction, Human creatine kinase CKMB REF: JOURNAL OF HEALTH SCIENCE Vol. 52 (2006) , No. 2 180-185/human/isoenyzme(s)/creatine kinase/ckmb/recombinant
Human creatine kinase CKMB research: Troponin T and CK/CKMB levels in patients with myocardial infarction after coronary artery bypass grafting. Human creatine kinase CKMB CK MB REF: Thorac cardiovasc Surg 2006; 54/human/isoenyzme(s)/creatine kinase/ckmb/recombinant
Human creatine kinase CKMB research: Minimizes Lactic Acidosis and Preserves CKMB and Myocardial Contractility after Ischemia/Reperfusion. Human CKMB REF: Advances in Experimental Medicine and Biology,Volume 583/human/isoenyzme(s)/creatine kinase/ckmb/recombinant
Human creatine kinase CKMB CK-MB isoenzyme research: Increased human creatine kinase MB (CKMB) isoenzyme level predicts postoperative mortality after cardiac surgery independent of new Q waves. Increased postoperative peak creatine kinase MB(CKMB(CK-MB)isoenzyme level. Human creatine kinase Ref: Journal of Thoracic and Cardiovascular Surgery Volume 129, Issue 2, February 2005, Pages 300-306 /human/isoenyzme(s)/creatine kinase/ckmb/recombinant
Human creatine kinase CKMB CK-MB isoenzyme research: Increased CKMB release is a trade-off for optimal stent implantation: an intravascular ultrasound study.Human creatine kinase CKMB CK-MB isoenzyme REF: Journal of the American College of Cardiology, Volume 39, Supplement 1, 6 March 2002, Pages 28-29/human/isoenyzme(s)/creatine kinase/ck/mb/recombinant
Human Creatine Kinase(CK),(CPK) research: Fluvastatin as Co-Medication in Heart Transplant Recipients With Elevated Creatine-Kinase.Human Creatine Kinase(CK),(CPK) REF: Transplantation Proceedings, Volume 39, Issue 2, March 2007, Pages 558-559/human/isoenyzme(s)/creatine kinase/ckmb/recombinant
Human Creatine Kinase(CK),(CPK) research: Elevated creatine kinase-MB with normal creatine kinase predicts worse outcomes in patients with acute coronary syndromes: Results from 4 large clinical trialsHuman Creatine Kinase(CK),(CPK) REF: American Heart Journal, Volume 151, Issue 1, January 2006, Pages 16-24/human/isoenyzme(s)/creatine kinase/ckmb/recombinant
Human Creatine Kinase(CK),(CPK) research: The fall in creatine levels and creatine kinase isozyme changes in the failing heart are reversible: Complex post-transcriptional regulation of the components of the CK system.Human Creatine Kinase(CK),(CPK) REF: Journal of Molecular and Cellular Cardiology, Volume 39, Issue 3, September 2005, Pages 537-544/human/isoenyzme(s)/creatine kinase/ckmb/recombinant
Human Creatine Kinase(CK),(CPK) research: Origin of the genes for the isoforms of creatine kinase.Human Creatine Kinase(CK),(CPK) REF: Gene, Volume 392, Issues 1-2, 1 May 2007, Pages 273-282/human/isoenyzme(s)/creatine kinase/ckmb/recombinant
Human Creatine Kinase(CK),(CPK) research: Creatine phosphokinase in ectopic pregnancy revisited: Significant diagnostic value of its MB and MM isoenzyme fractions.Human Creatine Kinase(CK),(CPK) REF:
American Journal of Obstetrics and Gynecology, Volume 194, Issue 1, January 2006, Pages 86-91/human/isoenyzme(s)/creatine kinase
Creatine Kinase (CPK)CK research:Comparison of MB Fraction of Creatine Kinase Mass and Troponin I Serum Levels With Necropsy Findings in Acute Myocardial Infarction.Creatine Kinase (CPK)CK ref:The American Journal of Cardiology, 20 December 2007/creatine kinase/cpk/ck/isoenzyme
Creatine Kinase (CPK)CK research:Brain creatine kinase activity in an animal model of mania.Creatine Kinase (CPK)CK ref:Life Sciences, 14 December 2007/creatine kinase/isoenzyme,ck/cpk
Creatine Kinase (CPK)CK study :Changing the substrate specificity of creatine kinase from creatine to glycocyamine: Evidence for a highly evolved active site.Creatine Kinase (CPK)CK source:
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, Volume 1774, Issue 12, December 2007, Pages 1519-1527/cpk/creatine/kinase/ck/isoenzyme
Creatine Kinase (CPK)CK study :Creatine kinase regulation by reversible phosphorylationin a freeze tolerant frog
Creatine Kinase (CPK)CK source :Cryobiology, Volume 55, Issue 3, December 2007, Page 376/cpk/creatine/kinase/ck/isoenzyme
Creatine Kinase (CPK)CK study :Detection of local polarity and conformational changes at the active site of rabbit muscle creatine kinase with a new arginine-specific fluorescent probe.Creatine Kinase (CPK)CK source:Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, online 22 November 2007/cpk/creatine/kinase/ck
Creatine Kinase (CPK)CK research:Is Higher HDL Level Correlated with Smaller Infarct Size Evaluated by Peak CPK?Creatine Kinase (CPK)CK ref:
Journal of Clinical Lipidology, Volume 1, Issue 2, May 2007, Pages 148-149/cpk/creatine/kinase/ck/isoenzyme
Creatine Kinase (CPK)CK research:Significance of CK-elevation in noncompaction with regard to cardiac and neuromuscular disease.Creatine Kinase (CPK)CK ref:
International Journal of Cardiology, In Press,4 December 2007/cpk/creatine/kinase/ck/isoenzyme
Creatine Kinase (CPK)CK research:Mitochondrial biogenesis in fast skeletal muscle of CK deficient mice.Creatine Kinase (CPK)CK source:
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 12 November 2007/cpk/creatine/kinase/ck/isoenzyme
Creatine Kinase (CPK)CK research:An unusual case of congenital muscular dystrophy with normal serum CK level, external ophtalmoplegia, and white matter changes on brain MRI.Creatine Kinase (CPK)CK ref:European Journal of Paediatric Neurology, Volume 11, Issue 6, November 2007, Pages 381-384/cpk/creatine/kinase/ck/isoenzyme
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