Item#: 431-11 MYOGLOBIN (Mb) Human
Product Info:
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| Product Name: | MYOGLOBIN (Mb) Human |
|---|---|
| Activity: | Typically >1 mg/ml |
| CAS No: | 11080-17-4 |
| Cat. No: | 431-11 |
| Expiration: | 3 years |
| Form: | Phosphate and sodium chloride buffer,pH 7.4 |
| Molecular Weight: | appro. 16.7-17.7 kDa |
| Purity: | >99% SDS Page |
| Source: | Human Heart Tissue |
| Storage: | 2-8 C |
| Synonyms: | Human Mb, myoglobin |
| UNSPSC code: | 51131907 |
Human heart MYOGLOBIN(Mb)protein from 100-5000mg single lot sizes. Custom buffers for human heart myoglobin available. Custom fills of human heart myoglobin available.
Myoglobin related products that we offer:
431-11R Recombinant Human Myoglobin
431-11 Native Human Myoglobin
CMY-80A Polyclonal chicken anti-myoglobin affinity purified
SMY-80A Polyclonal sheep anti-human myoglobin affinity purified
HUMAN MYOGLOBIN:
Human Myoglobin is a single-chain globular protein of 153 amino acids. Myoglobin contains a heme (iron-containing porphyrin) prosthetic group in the center around which the remaining apoprotein folds. Human Myoglobin has a molecular weight of 16,700 daltons. Human Myoglobin is found in skeletal and cardiac muscle cells and is capable of reversibly binding molecular oxygen and enhancing the rate of oxygen diffusion through the muscle cell. Human Myoglobin is an oxygen carrier in the cytoplasm and appears to be responsible for the transport of oxygen from the cell membrane to the mitochondrion.
Human cardiac Myoglobin (Mb) is a Haem containing protein and implicated as a cause of acute renal failure following damage to muscle tissue (e.g. rhabdomyolysis, severe crush trauma, malignant hyperthermia, status epilepticus and neuroleptic malignant syndrome), due to its toxicity to renal tubular epithelium. Human Myoglobin also serves as a useful biomarker for the detection of successful reperfusion following thrombolytic therapy.
Human Myoglobin Research: Human Myoglobin(Mb) shares limitations to biomarkers such as Human Troponin and Human CK due to high concentrations in skeletal muscle, Human Myoglobin(s) small molecular size and consequent rapid rise in the setting of myocardial necrosis. Human Myoglobin REF: The National Academy of Clinical Biochemistry indicates Human Myoglobin(Mb) has retained a value of a very early marker of MI (Myocaridal Infarction).
Human myoglobin Clinical studies have shown that the combined use of myoglobin and a more specific marker of myocardial necrosis (cardiac troponin or isoenzyme CK-MB) may be useful for early exluclusion of MI.
Human Heart Myoglobin Research: The case of myoglobin-facilitated oxygen diffusion.Human Heart Myoglobin REF:
Gene, 25 April 2007, Jonathan B. Wittenberg/human/myoglobin/cardiac.
Human Myogloin study: Expression of human myoglobin in H9c2 cells enhances toxicity to added hydrogen peroxide. Human Myoglobin Ref: Biochemical and Biophysical Research Communications, Volume 348, Issue 2, 22 September 2006, Pages 485-493/human/myoglobin/cardiac.
Human heart myoglobin study: Human myoglobin recognition of oxygen: Dynamics of the energy landscape. Human Myoglobin REF: PNAS,December 28, 2004 vol. 101, no. 52/human/myoglobin/cardiac.
Human heart Myoglobin Research: Utilization of myoglobin as a heme source by Haemophilus influenzae requires binding of myoglobin to haptoglobin. Human heart Myoglobin REF: FEMS Microbiology Letters Volume 258 Issue 2 Page 235 - May 2006/human/myoglobin/cardiac.
Human heart myoglobin study: Emerging Roles for Human Myoglobin in the Heart. Human Myoglobin (Mb) is an intensely studied hemoprotein that is restricted mainly to the heart and oxidative myofibers in skeletal muscle. Human heart Myoglobin REF: Trends in Cardiovascular Medicine Volume 13, Issue 3, April 2003, Pages 111-116/human/myoglobin/cardiac.
Human heart Myoglobin research: Diagnostic utility of new immunoassays for the cardiac markers cTnI, myoglobin and CK-MB mass. human myoglobin REF: Clinical Biochemistry, Volume 38, Issue 11, November 2005, Pages 1027-1030/human/myoglobin/cardiac.
Human heart Myoglobin Research: Myoglobin concentration and succinate dehydrogenase activity in skeletal muscle and age determine VO2max of chronic heart failure patients. Human Myoglobin REF: European Journal of Heart Failure Supplements, Volume 4, Issue 1, June 2005, Page 118/human/myoglobin/cardiac.
Human Heart Myoglobin Research: Clinical significance of myoglobin and troponin-T in short-lasting severe myocardial ischemia. Human Myoglobin REF: International Journal of Cardiology, Volume 98, Issue 2, 15 February 2005, Pages 285-290/human/myoglobin/cardiac.
Human Heart Myoglobin Research: Effects of contemporary troponin assay sensitivity on the utility of the early markers myoglobin and CKMB isoforms in evaluating patients with possible acute myocardial infarction.Human Heart Myoglobin Ref: Clinica Chimica Acta, Volume 380, Issues 1-2, 1 May 2007, Pages 213-216/human/myoglobin/cardiac.
Human Heart Myoglobin Research: The Impact of B-Type Natriuretic Peptide in Addition to Troponin I, Creatine Kinase-MB, and Myoglobin on the Risk Stratification of Emergency Department Chest Pain Patients With Potential Acute Coronary Syndrome.Human Heart Myoglobin Ref: Annals of Emergency Medicine, Volume 49, Issue 2, February 2007, Pages 153-163/human/myoglobin/cardiac.
myoglobin research:Direct electron-transfer of myoglobin within a new zwitterionic gemini surfactant film and its analytical application for H2O2 detection,Colloids and Surfaces B: Biointerfaces, Volume 63, Issue 2, 1 June 2008, Pages 262-268human/myoglobin/protein/
myoglobin research:Clay–chitosan–gold nanoparticle nanohybrid: Preparation and application for assembly and direct electrochemistry of myoglobin
Electrochimica Acta, Volume 53, Issue 14, 30 May 2008, Pages 4732-4739human/myoglobin/protein/
myoglobin research:The Expression of Myoglobin and ROR2 Protein in Dupuytren's Disease,Journal of Surgical Research, Volume 146, Issue 2, 15 May 2008, Pages 271-275human/myoglobin/protein/
myoglobin research:Dynamics of myoglobin in confinement: An elastic and quasi-elastic neutron scattering study,Chemical Physics, Volume 345, Issues 2-3, 18 April 2008, Pages 259-266human/myoglobin/protein/
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