Item#: 126-11R BETA-2 MICROGLOBULIN, Human (Recombinant) (B2M)

Bulk Quantities of recombinant human (B2M) from 1-10 gram single lot sizes. Custom fills for recombinant (B2M) beta-2-microglobulin available.

serum beta2-microglobulin, an endogenous marker for renal function, has been shown to be an independent predictor of mortality in older adults

Class I MHC molecules consist of two separate polypeptide chains. The class I alpha chain is an MHC-encoded , transmembrane polypeptide containing three extracellular domains as referred to alpha1, alpha2, and alpha3. The second polypeptide chain is a non-MHC-encoded, 12 kDa polypeptide called beta-2-microglobulin. Since beta-2-microglobulin (B2M) does not contain a transmembrane domain, it associates with a chain through non-covalent interaction. This interaction is important for the stability of the MHC class I structure, its peptide-loading and its ability to present peptide antigen to CD8+ T cells.

beta-2-microglobulin r-hB2M is produced as an inclusion body in E. coli by expressing gene encoding human beta-2-microglobulin (B2M). From the inclusion body, recombinant human beta-2-microglobulin rB2M is refolded and treated by CNBr cleavage to show identical amino acid sequence to native one from human tissue origin.

beta-2-microglobulin Application: In vitro extension of amyloid fibrils, High qualified antigen for antibody production

Human Beta 2-Microglobulin protein(B2M) Products we offer:
126-11R (B2M) Beta 2 Microglobulin Human Recombinant
126-11 Native Human Beta Microglobulin (B2M)