|Purity||> 99% (SDS-PAGE)|
|Protein||2.0 - 4.0 mg/mL (Lowry)|
|Form||Solution in phosphate buffered saline, pH 7.5 with 0.09% sodium azide.|
|Appearance||Clear, reddish-brown solution|
|Molecular Weight||Approx. 16.7 - 17.7 kDa|
|Gene||MB, RP4-569D19.7, PVALB, myoglobgin|
Lee Biosolutions produces human cardiac Myoglobin for research and manufacturing uses.
Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details. Single lot sizes from 1,000 - 5,000 mg.
This product is a single-chain globular protein of 153 amino acids and contains a heme (iron-containing porphyrin) prosthetic group in the center around which the remaining apoprotein folds.
Myoglobin is found in skeletal and cardiac muscle cells and is capable of reversibly binding molecular oxygen and enhancing the rate of oxygen diffusion through the muscle cell. Human Myoglobin is an oxygen carrier in the cytoplasm and appears to be responsible for the transport of oxygen from the cell membrane to the mitochondrion.
Myoglobin (Mb) is implicated as a cause of acute renal failure following damage to muscle tissue (e.g. rhabdomyolysis, severe crush trauma, malignant hyperthermia, status epilepticus and neuroleptic malignant syndrome), due to its toxicity to renal tubular epithelium.