Low Density Lipoprotein (LDL)

Catalogue Number: 360-10
Description
Product Name Low Density Lipoprotein
Source Human Plasma
Catalogue Number 360-10
Form Liquid
Purity Plasma Fraction
Total Cholesterol > 4,000 mg/dL (Enzymatic)
Inquire for custom concentrations and cholesterol ratios
Triglyceride Report in mg/dL
Triglyceride Ratio < 0.9 (Triglycerides/Total Cholesterol)
Electrophoresis One major band observed, corresponds to LDL (Helena QuickGel® Cholesterol)
Appearance Yellow to orange liquid
Preservatives None, EDTA free
Handling - Thaw quickly, in a 37°C water bath, removing as soon as thawed.
- Store at 2 – 8°C for up to one week, -20°C for up to three months, and up to 24 months at -70°C.
- Dilute with 0.15 M sodium chloride.
Related Products 361-10 - High Density Lipoprotein from human plasma
185-10 - Cholesterol Concentrate from bovine serum
361-56 - Triglycerides from human plasma
Recertification 2 years
Storage -20°C (up to three months)
-70°C (more than three months)
Infectious Disease Testing Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV, HBsAg, HIV-1 (NAT), HBV (NAT), HCV (NAT), and syphilis by FDA approved methods.
Molecular Weight 2.75 million (ref. Tetz second Edition)
Synonyms LDL, LDL-C, Beta-Lipoprotein, Concentrate, Fraction
Country of Origin United States
Application Note Stable in liquid and lyophilized controls, calibrators and standards.
References The Journal of Lipid Research, November 2013, 54, 3016-3029.
Acta Biomaterialia Volume 71, 15 April 2018, Pages 420-431
Overview

Lee Biosolutions is world leader in the manufacturing of human plasma Low Density Lipoprotein (LDL) and other cholesterol/triglyceride products for research and in vitro diagnostic (IVD) manufacturing uses.

Custom LDL/HDL and triglyceride ratios, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.


OVERVIEW

Low-density lipoprotein (LDL), often deemed the “bad cholesterol”, is a lipoprotein that carries cholesterol throughout the body via blood circulation. Due to its role in dispositioning cholesterol TO tissues and organs of the body, having high levels of LDL can lead to plaque formation in the arteries, possibly increasing the risk of heart disease and stroke. (American Heart Association, 2014)

It is recommended by the National Heart, Lung, and Blood Institute to maintain a LDL cholesterol level lower than 100 mg/dL, optimally. (National Heart, Lung, and Blood Institute, 2016)


APPLICATIONS

Diagnostic – Clinical calibration control

Source of antigens for developing antibodies

Cholesterol Research in regards to pharmaceutical drug development and familial hypercholesterolaemia (Varghese, 2014)

Developing new methods of LDL measurement (Nauck, Warnick, & Rifai, 2002)


EMERGING RESEARCH

LDL size has been shown to be linked to cardiovascular health. The larger the LDL particles, the greater correlation to a cardiovascular event. (Foroutan, MS, RDN, 2015)

Lowering LDL to the levels of a new-born baby has been shown to dramatically decrease the risk of heart disease. (News Medical Life Sciences, 2016)

Direct homogeneous assays rather than determining LDL-C values based on the Friedewald calculation may improve lipoprotein analyses and allow for a more accurate LDL value, especially in regards to patients suffering from hyperlipidemia (Nauck, Warnick, & Rifai, 2002).


Add to Cart
SKU PRICE (USD) UNIT QTY
360-10-0.01 $ 37.00 10 mg
360-10-0.1 $ 158.00 100 mg
360-10-0.5 $ 394.00 5 x 100 mg
360-10-1 $ 735.00 1 gram
360-10 - Low Density Lipoprotein - Stability Data