High Density Lipoprotein (HDL)

Catalogue Number: 361-10
Description
Product Name High Density Lipoprotein
Source Human Plasma
Catalogue Number 361-10
Form Liquid
Purity Plasma Fraction
Total Cholesterol > 1,500 mg/dL (Enzymatic)
Triglyceride Report in mg/dL
Triglyceride Ratio < 0.55 (Triglycerides/Total Cholesterol)
Electrophoresis One major band observed, corresponds to HDL (Helena QuickGel® Cholesterol)
Appearance Amber to orange liquid
Preservatives None, EDTA free
Handling - Thaw quickly, in a 37°C water bath, removing as soon as thawed.
- Store at 2 – 8°C for up to one week, -20°C for up to three months, and up to 24 months at -70°C.
- Dilute with 0.15 M sodium chloride.
Related Products 361-10 - Low Density Lipoprotein from human plasma
185-10 - Cholesterol Concentrate from bovine serum
361-56 - Triglycerides from human plasma
Storage -20°C (up to three months)
-70°C (more than three months)
Recertification 2 years
Molecular Weight 175,000-360,000 (Tetz second Edition)
Synonyms HDL, HDL-C, HDL Concentrate, HDL Fraction, alpha-Lipoprotein
Country of Origin United States
Application Note Stable in liquid and lyophilized controls, calibrators and standards.
References Acta Biomaterialia Volume 71, 15 April 2018, Pages 420-431
Overview

Lee Biosolutions is world leader in the manufacturing of human plasma High Density Lipoprotein (HDL) and other cholesterol/triglyceride products for research and in vitro diagnostic (IVD) manufacturing uses.

Custom LDL/HDL and triglyceride ratios, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.


OVERVIEW

High density lipoprotein, aka the “good cholesterol”, functions as the transit for cholesterol AWAY from blood, tissues, and organs of the body TO the liver where cholesterol breakdown occurs, ultimately helping to remove cholesterol from the arteries. Having HDL levels less than 40 mg/dL for men and less than 50 mg/dL for women is a major risk factor for heart disease. (Mayo Clinic, 2016)

HDL makes up 20%-30% of total cholesterol in the body, a combination of HDL, LDL, and triglycerides, which is typically measured through a blood test. (Harvard University, 2015)

Total fasting cholesterol (no eating for 12 hours) should be measured once every five years, at the very least, beginning at the age of 20. (American Heart Association, 2014)


APPLICATIONS

  • Diagnostic Controls, Calibrators & Standards
  • Lipid Panels
  • Infusion Therapy
  • HDL-regression clinical trials
  • Cardiac Research
  • Immunoassays
  • Research of HDL-raising drugs
  • Cell culture
  • Clinical chemistry
  • Testing/assay validation
  • Life Science
  • ELISA, Blotting, etc.
  • Characterization
  • Manufacturing

EMERGING RESEARCH

  • Recently, HDL has been found to be an important mediator in the reversal of metabolic dysfunction and the regression of cardiovascular disease due to atherosclerosis. (Klancic, Woodward, Hofmann, & Fisher, 2016)
  • HDL infusions are being tested in clinical trials due to HDL’s ability to mediate the reversal of cholesterol transport. HDL infusions are isolated, partially delipidated HDL proteins and native apoAI or genetic variants such as apoAI Milano complexed with phospholipids. These agents have the potential to be applied to a vast range of vascular diseases, especially acute coronary syndromes. (Kingwell & Chapman, 2013)
Add to Cart
SKU PRICE (USD) UNIT QTY
361-10-0.01 $ 61.00 10 mg
361-10-0.1 $ 193.00 100 mg
361-10-0.5 $ 497.00 5 x 100 mg
361-10-1 $ 938.00 1 gram