Item#: 129-10 Brain Natriuretic Peptide-32 (Human)
Product Info:
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| Product Name: | Brain Natriuretic Peptide-32 (Human) |
|---|---|
| CAS No: | 114471-18-0 |
| Cat. No: | 129-10 |
| Form: | Acetate Salt |
| Purity: | >99% pure |
| Source: | Human |
| Storage: | -20C |
| Synonyms: | BNP-32, Nesiritide |
Human Brain Natriuretic Peptide BNP-32 also known as B-type natriuretic peptide or GC-B has a Peptide Sequence: H-Ser-Pro-Lys-Met-Val-Gin-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-lle-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His-OH
(disulfide bond)
Brain natriuretic peptide, BNP 32 (also known as B-type natriuretic peptide or "GC-B") is a 32-amino-acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of myocytes (heart muscles cells) in the ventricles. At the time of release, a co-secreted 76 amino acid n-terminal fragment (NT-proBNP) is also released with B-type natriuretic peptide BNP. B-type natriuretic peptide BNP binds to and activates NPRA in a similar fashion to atrial natriuretic peptide but with 10-fold lower affinity. The biological half-life of BNP however, is twice as long as that of ANP. Both ANP and B-type natriuretic peptide BNP have limited ability to bind and activate NPRB.
BNP 32 Tests showing elevated levels of B-type natriuretic peptide BNP or NT-proBNP in the blood are used as a diagnosis of heart failure and may be useful to establish prognosis in heart failure, as both markers are typically higher in patients with worse outcome.
BNP 32 Both B-type natriuretic peptide BNP and NT-proBNP have been approved as a marker for acute congestive heart failure (CHF). The plasma concentrations of both BNP are increased in patients with asymptomatic and symptomatic left ventricular dysfunction.
BNP 32 Brain natriuretic peptide was originally identified in extracts of porcine brain, but in humans it is produced mainly in the cardiac ventricles.
BNP 32 B-Type Natriuretic Peptide (BNP) blood test: BNP is a substance secreted from the ventricles or lower chambers of the heart in response to changes in pressure that occur when heart failure develops and worsens. The level of B-type natriuretic peptide BNP in the blood increases when heart failure symptoms worsen, and decreases when the heart failure condition is stable. The B-type natriuretic peptide BNP level in a person with heart failure - even someone whose condition is stable - is higher than in a person with normal heart function. REF: Clevelandclinic.org
POPULAR CARDIAC MARKERS
125-15 APO A1 LIPOPROTEIN Human Plasma
129-10 Brain Natriuretic Peptide 32 Human BNP 32
140-11 C-REACTIVE PROTEIN(CRP) Human
140-11R C-Reactive Protein Recombinant
190-27 CK MM Isoenzyme Human heart
191-25 CK BB Isoenzyme Human brain
191-24 CK BB Isoenzyme Porcine Brain
190-24 CK MB Isoenzyme Human heart
191-26R2 CK MB Isoenzyme Recombinant
190-29 CK MM Isoenzyme Human skeletal muscle
190-20 TOTAL CPK Human Heart
276-10 Fatty Acid Binding Protein
361-10 High Density Lipoprotein
350-70 TOTAL LD(LDH) Human Heart
355-15 LD-1 ISOENZYME Human Heart
355-25 LD-2 ISOENZYME Human Heart
426-10 MYELOPEROXIDASE Human Neutrophil
431-11 MYOGLOBIN Human Heart
431-11R Myoglobin Recombinant
129-15 NT-ProBNP Recombinant
550-41 TROPONIN C Rabbit muscle
550-40 TROPONIN C Human Heart
550-40R Troponin C Recombinant
550-11 TROPONIN I Human Heart
550-11R Troponin I Human Recombinant
550-21R Troponin T Human Recombinant
550-21 TROPONIN T Human Heart