Pepsinogen II (PGII, PGC)
Catalogue Number: 440-52
Description
| Product Name | Pepsinogen II |
| Source | Human Gastric Mucosa |
| Catalogue Number | 440-52 |
| Purity | > 90% (SDS-PAGE) |
| Purity Note | Typically > 96% (SDS-PAGE) |
| Form | Lyophilized |
| Protein | Reported mg protein/vial (A280nm, E0.1%=1.43) |
| Specific Activity | > 1,000 U/mg protein (After activation) |
| Unit Definition | One unit will produce a change in A280 of 0.001 per minute at pH 2.0 and 37°C, measured as TCA-soluble products from hemoglobin. |
| Appearance | White to off-white powder |
| Solubility | Clear, colorless liquid (1 mg/mL 0.02 M tris-cholride, pH 8.0) |
| Reconstitution | After reconstitution maintain at or above pH 8.0 to avoid activation. |
| Formulation | Lyophilized from tris-chloride, pH 8.5 |
| Related Products | 440-50 - Pepsinogen I from human gastric mucosa 441-10 - Pepsin 1:10,000 from porcine gastric mucosa 435-10 - Mucin from porcine gastric mucosa |
| Recertification | 3 years |
| Storage | -20°C |
| Infectious Disease Testing | Negative or non-reactive at the donor level for anti HIV 1 and 2, anti HCV, syphilis (RPR) and HBsAg by FDA approved methods |
| Molecular Weight | 40,600 |
| Synonyms | Pepsinogen C, PG II, PGC, Gastricsin, Pepsinogen 2 |
| E.C. Number | 3.4.23.3 |
| Gene | PGC, RP11-298J23.1, PEPC, PGII |
| Gene ID | 5225 |
| Accession No | P20142 |
Applications
Overview
Lee Biosolutions is the leading producer and supplier of Human Pepsinogen II/C antigen as a stomach gastric cancer marker for medical research, clinical and diagnostic manufacturing.
Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
Human Pepsinogens are aspartic proteases produced in the gastric mucosa and secreted into the gastric lumen that play a major role in the digestion of porteins after activation of acidic pH. Pepsinogen is synthesized as isoymogens and are classified into two groups, I and II.
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