Pepsinogen I (PGI, PGA)
|Product Name||Pepsinogen I|
|Source||Human Gastric Mucosa|
|Purity||> 90% (SDS-PAGE)|
|Specific Activity||> 500 U/mg protein (After activation)|
|Protein||Reported mg protein/vial (A280, E0.1%=1.48)|
|Unit Definition||One unit will produce a change in A280 of 0.001 per minute at pH 2.0 and 37°C, measured as TCA-soluble products from hemoglobin.|
|Identity||Confirmed by Western Blot|
|Form||Lyophilized from tris-chloride, pH 8.5|
|Solubility||Clear, colorless liquid (1 mg/mL saline)|
|Synonyms||Pepsinogen A, PG I, PGA, Pepsinogen 1|
|Gene||PGA3, PGA4, PGA5|
Lee Biosolutions is the leading producer and supplier of human gastric Pepsinogen I (A) antigen as a cancer marker for medical research, clinical and biomedical manufacturing.
Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
Human Pepsinogens are aspartic proteases produced in the gastric mucosa and secreted into the gastric lumen that play a major role in the digestion of proteins after activation of acidic pH. It is synthesized as isoymogens and are classified into two groups, Pepsinogen I and Pepsinogen II).
Human PGA and PGC antigen have been investigated as a possible biomarker for early detection of, Gastric cancer (GC), adenoma (GA) and severe atrophic (diffuse or patchy) corpus gastritis.
It has been reported that human Pepsinogen I (PGA) levels were lower in atrophic corpus gastritis than in atrophic antral gastritis, and human pepsinogen I(PGA) levels were lower in advanced gastric cancer than early stage gastric cancer.