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Pepsinogen I (PGI, PGA)

Catalogue Number: 440-50
Product Name Pepsinogen I
Source Human Gastric Mucosa
Catalogue Number 440-50
Purity > 90% (SDS-PAGE)
Form Lyophilized
Protein Reported mg protein/vial (A280, E0.1%=1.48)
Specific Activity > 500 U/mg protein (After activation)
Unit Definition One unit will produce a change in A280 of 0.001 per minute at pH 2.0 and 37°C, measured as TCA-soluble products from hemoglobin.
Identity Confirmed by Western Blot
Appearance White lyophilisate
Form Lyophilized from tris-chloride, pH 8.5
Solubility Clear, colorless liquid (1 mg/mL saline)
Recertification 3 years
Storage -20°C
Molecular Weight 45,000
Synonyms Pepsinogen A, PG I, PGA, Pepsinogen 1
E.C. Number
Gene PGA3, PGA4, PGA5

Lee Biosolutions is the leading producer and supplier of human gastric Pepsinogen I (A) antigen as a cancer marker for medical research, clinical and biomedical manufacturing.

Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.

Human Pepsinogens are aspartic proteases produced in the gastric mucosa and secreted into the gastric lumen that play a major role in the digestion of proteins after activation of acidic pH. It is synthesized as isoymogens and are classified into two groups, Pepsinogen I and Pepsinogen II).

Human PGA and PGC antigen have been investigated as a possible biomarker for early detection of, Gastric cancer (GC), adenoma (GA) and severe atrophic (diffuse or patchy) corpus gastritis.

It has been reported that human Pepsinogen I (PGA) levels were lower in atrophic corpus gastritis than in atrophic antral gastritis, and human pepsinogen I(PGA) levels were lower in advanced gastric cancer than early stage gastric cancer.

440-50-0.1 $ 140.00 100 ug
440-50-0.5 $ 295.00 5 x 100 ug
440-50-1 $ 450.00 1 mg
Representative SDS-PAGE & WB - 440-50