Pepsinogen I (PGI, PGA)

Catalogue Number: 440-50
Description
Product Name Pepsinogen I
Source Human Gastric Mucosa
Catalogue Number 440-50
Purity > 90% (SDS-PAGE)
Purity Note Typically > 96% (SDS-PAGE)
Form Lyophilized
Protein Reported mg protein/vial (A280nm, E0.1%=1.48)
Specific Activity > 500 U/mg protein (After activation)
Unit Definition One unit will produce a change in A280 of 0.001 per minute at pH 2.0 and 37°C, measured as TCA-soluble products from hemoglobin.
Appearance White to off-white powder
Solubility Clear, colorless liquid (1 mg/mL saline)
Reconstitution After reconstitution maintain at or above pH 8.0 to avoid activation.
Formulation Lyophilized from tris-chloride, pH 8.5.
Related Products 440-52 - Pepsinogen II from human gastric mucosa
441-10 - Pepsin 1:10,000 from porcine gastric mucosa
435-10 - Mucin from porcine gastric mucosa
Recertification 3 years
Storage -20°C
Infectious Disease Testing Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV and HBsAg by FDA approved methods.
Molecular Weight 40,300
Synonyms Pepsinogen A, PG I, PGA, Pepsinogen 1
E.C. Number 3.4.23.1
Gene PGA3, PGA4, PGA5
Overview

Lee Biosolutions is the leading producer and supplier of human gastric Pepsinogen I (A) antigen as a cancer marker for medical research, clinical and biomedical manufacturing.

Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.

Human Pepsinogens are aspartic proteases produced in the gastric mucosa and secreted into the gastric lumen that play a major role in the digestion of proteins after activation of acidic pH. It is synthesized as isoymogens and are classified into two groups, Pepsinogen I and Pepsinogen II).

Human PGA and PGC antigen have been investigated as a possible biomarker for early detection of, Gastric cancer (GC), adenoma (GA) and severe atrophic (diffuse or patchy) corpus gastritis.

It has been reported that human Pepsinogen I (PGA) levels were lower in atrophic corpus gastritis than in atrophic antral gastritis, and human pepsinogen I(PGA) levels were lower in advanced gastric cancer than early stage gastric cancer.

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SKU PRICE (USD) UNIT QTY
440-50-0.1 $ 154.00 100 ug
440-50-1 $ 497.00 1 mg
440-50-10 Inquire 10 x 1 mg
Representative SDS-PAGE & WB - 440-50