Pepsinogen I (PGI, PGA)

Catalogue Number: 440-50
Product Name Pepsinogen I
Source Human Gastric Mucosa
Catalogue Number 440-50
Purity > 90% (SDS-PAGE)
Purity Note Typically > 96% (SDS-PAGE)
Form Lyophilized
Protein Reported mg protein/vial (A280nm, E0.1%=1.48)
Specific Activity > 500 U/mg protein (After activation)
Unit Definition One unit will produce a change in A280 of 0.001 per minute at pH 2.0 and 37°C, measured as TCA-soluble products from hemoglobin.
Appearance White to off-white powder
Solubility Clear, colorless liquid (1 mg/mL saline)
Reconstitution After reconstitution maintain at or above pH 8.0 to avoid activation.
Formulation Lyophilized from tris-chloride, pH 8.5.
Related Products 440-52 - Pepsinogen II from human gastric mucosa
441-10 - Pepsin 1:10,000 from porcine gastric mucosa
435-10 - Mucin from porcine gastric mucosa
Recertification 3 years
Storage -20°C
Infectious Disease Testing Negative or non-reactive at the donor level for anti HIV 1 and 2, anti HCV, syphilis (RPR) and HBsAg by FDA approved methods
Molecular Weight 40,300
Synonyms Pepsinogen A, PG I, PGA, Pepsinogen 1
E.C. Number
Gene PGA3, PGA4, PGA5

Lee Biosolutions is the leading producer and supplier of human gastric Pepsinogen I (A) antigen as a cancer marker for medical research, clinical and biomedical manufacturing.

Custom preparations, technical support, bulk quantities and aliquoting available, email for more details.

Human Pepsinogens are aspartic proteases produced in the gastric mucosa and secreted into the gastric lumen that play a major role in the digestion of proteins after activation of acidic pH. It is synthesized as isoymogens and are classified into two groups, Pepsinogen I and Pepsinogen II).

Human PGA and PGC antigen have been investigated as a possible biomarker for early detection of, Gastric cancer (GC), adenoma (GA) and severe atrophic (diffuse or patchy) corpus gastritis.

It has been reported that human Pepsinogen I (PGA) levels were lower in atrophic corpus gastritis than in atrophic antral gastritis, and human pepsinogen I(PGA) levels were lower in advanced gastric cancer than early stage gastric cancer.

Add to Cart
440-50-0.1 $ 214.00 100 ug
440-50-1 $ 688.00 1 mg
440-50-10 Inquire 10 x 1 mg
Representative SDS-PAGE & WB - 440-50