We Are Solutions...On Demand
Item #: 550-11
8M Urea, 50mM Tris-HCl, 15mM beta-mercaptoethanol, 1mM EDTA
>0.50 mg/mL (A280)
>/= 98% by SDS-PAGE
7.4 +/- 0.1
Lee Biosolutions supplies human cardiac marker TROPONIN I in research and bulk quantities for IVD Manufacturers.
Technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
Other Cardiac Markers Offered:
190-24 - Human Heart Creatine Kinase MB
550-11 - Human Heart Troponin I
550-21 - Human Heart Troponin T
550-40 - Human Heart Troponin C
431-11 - Human Heart Myoglobin
Current studies show that Troponin I is a part of the troponin complex. Troponin I binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle.
Human Troponin is a family of proteins (Troponin I, T and C) found in skeletal and heart muscle fibers; cardiac Troponin helps muscles contract. Certain subtypes of human troponin (cardiac troponin I and T) are very sensitive and specific indicators of damage to the heart muscle myocardium)