Myeloperoxidase (MPO) Antigen, pANCA
|Purity||> 96% (SDS-PAGE)|
|Protein||1.0 - 2.0 mg/mL (A430, E0.1%=1.19)|
|Activity||> 1,000 U/mL|
|Specific Activity||> 1,000 U/mg protein|
|Unit Definition||One unit of Myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of ¼ micromole of tetraguaiacol per minute at pH 7.0 and 25°C.|
|Appearance||Clear, greenish Liquid|
|Form||0.2 um solution in 50 mM sodium acetate, 100 mM sodium chloride, pH 6.0, with bromo-nitro-dioxane and methylisothiazolone as preservatives.|
Lee Biosolutions is the largest primary manufacturer of Myeloperoxidase (MPO) enzymes for medical research and diagnostic manufacturing globally.
Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
Rz is an abbreviation for Reinheitszahl (purity number). It is the ratio of absorbance at 430 nm (heme)/ 280 nm (total protein). It is a measure of the purity of the enzyme. Anything above 0.8 is highly pure.
MPO is a peroxidase enzyme occurs the most in neutrophil granulocytes (a subtype of white blood cells). It is a lysosomal protein stored in azurophilic granules of the neutrophil. Myeloperoxidase has a green heme pigment and is found in pus and some forms of mucus. It is recognized as an important factor in many inflammatory diseases such as cardiovascular and neurological diseases. MPO-specific imaging agents would thus be highly useful to diagnose early disease, monitor disease progression, and quantify treatment effects.