Troponin I (cTnI)

Catalogue Number: 550-11
Product Name Troponin I antigen
Source Human Heart
Catalogue Number 550-11
Purity > 98% (SDS-PAGE)
Form Liquid
Protein > 0.5 mg/mL (A280, E0.1%=0.42)
Formulation Solution in Urea, Tris-HCl, beta-mercaptoethanol, EDTA, pH 7.3-7.5.
Related Products 550-21 - Troponin T from human heart
431-11 - Myoglobin from human heart
426-10 - Myeloperoxidase from human leukocytes
Storage -20°C
Recertification 2 years
Infectious Disease Testing Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV, HBsAg, HCV NAT, and HIV-1 NAT by FDA approved methods.
Synonyms Tn-I, hTn-I, cTnI, cardiac Tn-I, TnI
Molecular Weight ~24,000
CAS Number 77108-40-8

Lee Biosolutions produces Human Heart Troponin I (Tn-I) for research and manufacturing uses.

Custom preparations, technical support, bulk quantities and aliquoting available, email for more details.

Current studies show that Troponin I is a part of the troponin complex. Troponin I binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. Human Troponin is a family of proteins (Troponin I, T and C) found in skeletal and heart muscle fibers; cardiac Troponin helps muscles contract. Certain subtypes of human troponin (cardiac troponin I and T) are very sensitive and specific indicators of damage to the heart muscle myocardium).

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550-11-0.1 Inquire 100 ug
550-11-1 Inquire 1 mg