Neuron Specific Enolase (NSE)

Catalogue Number: 430-11
Product Name Neuron Specific Enolase
Source Human Brain
Catalogue Number 430-11
Purity > 96% (SDS-PAGE)
Form Liquid
Protein > 0.5 mg/mL (A280 E0.1%=1.22)
Activity Enzymatically active
Formulation Solution in sodium phosphate, sodium chloride and magnesium sulfate, pH 7.4.
Appearance Clear, colorless liquid
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Storage -20°C
Recertification 5 years
Synonyms 2-Phospho-D-glycerate hydro-lyase, NSE, Enolase 2, Gamma-enolase;
Molecular Weight ~45,000
CAS Number 9014-08-8
E.C. Number
Gene ENO2, NSE
Gene ID 2026
Accession No P09104

Lee Biosolutions is the leading supplier of human brain Human Neuron Specific Antigen (NSE) for clinical research and diagnostic manufacturing.

Custom preparations, technical support, bulk quantities and aliquoting available, email for more details.

Associated Tumor Types: Small-Cell Carcinoma Neuroendocrine Tumor Breast Cancer

According to current literature, NSE is a glycolytic enzyme that catalyzes the conversion of phosphoglycerate to phosphoenol pyruvate and is present in neurons, neuroendocrine cells, and amine precursor uptake and decarboxylation (APUD) cells.

Neuron-specific enolase (NSE) is a neuronal form of the glycolytic enzyme enolase, which was first found in extracts of brain tissue, and was later shown to be present in APUD (amine precursor uptake and decarboxylation) cells and neurons of the diffuse neuroendocrine system but not in other peripheral cells.   NSE is a valuable tumor marker for cancers of neuroendocrine origin, especially for small-cell lung cancer and neuroblastoma.

Elevated concentrations are observed in patients with neuroblastoma, pancreatic islet cell carcinoma, medullary thyroid carcinoma, pheochromocytoma, and other neuroendocrine tumors as well as in certain benign conditions. NSE levels are frequently increased in patients with SCLC and infrequently in patients with non-SCLC. NSE has therefore been used to monitor disease progression and management in SCLC.

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430-11-0.025 $ 93.00 25 ug
430-11-0.1 $ 319.00 100 ug
430-11-1 Inquire 1 mg