Aprotinin

Catalogue Number: 125-10
Description
Product Name Aprotinin
Source Bovine Lung
Catalogue Number 125-10
Purity > 95% (HPLC)
Form Lyophilized
Activity 3.0 - 8.0 TIU/mg solid
Protein > 0.9 mg protein/mg solid
pH 5.0 - 7.0
Solubility Clear, colorless (2 mg/mL H2O)
Appearance White to off-white hygroscopic powder
Storage 2-8°C
Recertification 2 years
Molecular Weight 6511.44
Synonyms Pancreatic Trypsin Inhibitor, Basic Protease Inhibitor, BPI, BPTI
CAS Number 9087-70-1
Gene PTI, BOS_13313, BPI, BPTI
Gene ID 404172
Accession No P00974
Application Inhibitor of serine proteases, including Trypsin, Chymotrypsin and Kallikrein
Overview

Lee Biosolutions  bovine lung Aprotinin is used for the isolation of proteins as well as for biopharmaceutical downstream purification to inhibit undesired proteolytic activity of serine proteases such as trypsin, plasmin, trypsinogen, urokinase, chymotrypsin, kallikrein, elastase and others.

Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.

The stability of the Aprotinin molecule is due to the 3 disulfide bonds linking the 6 cysteine members of the chain (Cys5-Cys55, Cys14-Cys38 and Cys30-Cys51). The lysine (15)-alanine (16) sequence on this strongly basic polypeptide represents the active center.

A single chain polypeptide isolated from bovine lung with antifibrinolytic and anti-inflammatory activities. As a broad-spectrum serine protease inhibitor, aprotinin bovine competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, and tissue and leukocytic proteinases, resulting in attenuation of the systemic inflammatory response (SIR), fibrinolysis, and thrombin generation. This agent also inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. Bovine Aprotinin REF: National Cancer Society/bovine/aprotinin.

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SKU PRICE (USD) UNIT QTY
125-10-100 $ 158.00 100 mg
125-10-250 $ 341.00 250 mg
125-10-1,000 $ 893.00 1,000 mg