Complement Component 4c (C4c)

Catalogue Number: 194-42
Product Name Complement Component 4c
Source Human Plasma
Catalogue Number 194-42
Purity > 95% (SDS-PAGE)
Form Lyophilized
Protein Reported in mg/vial (E0.1%280nm = 0.92)
Identity Confirmed by Western Blot
Formulation Lyophilized from phosphate buffered saline, pH 7.4.
Related Products GC4-80A - anti-Human C4 polyclonal antibody
194-41 - C4 antigen from human plasma - Liquid
194-31 - C3 antigen from human plasma
Storage -20°C
Recertification 3 years
Infectious Disease Testing Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV, HBsAg, HIV-1 (NAT), HBV (NAT), HCV (NAT), and syphilis by FDA approved methods.
Product Details Complement C4 (200 kDa) is composed of three polypeptide chains – α (93 kDa), β (78 kDa), and γ (33 kDa). During complement activation, C4 is cleaved by the serine protease C1s to C4a (9 kDa) and C4b (190 kDa). C4b is further cleaved by factor I to C4d (45 kDa) and C4c (140 kDa). The current protocol yields C4c, however intact C4 and/or C4b and C4d may be co-purified.
Synonyms C4, Complement C4, C4c
Gene C4A, C4B
Gene Synonyms DAMC-258G8.6, C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG, DADB-112B14.11-001, C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4F, CH, CO4, CPAMD3
Gene ID 720, 721

Custom preparations, technical support, bulk quantities and aliquoting available, email for more details.

It is thought that the complement system might play a role in many diseases with an immune component, such as Alzheimer's disease, asthma, lupus erythematosus, various forms of arthritis, autoimmune heart disease and multiple sclerosis.

Deficiencies of the terminal pathway predispose to both autoimmune disease and infections (particularly meningitis)

Human Complement C4c is used as an immunogen and our product is an inactive form.

C4c is produced in Human plasma having a molecular mass of 210 kDa. It interacts with complement C1 and complemenet C2 to form complement C3 convertase of the classic activation pathway. Systemic lupus erythematosus is often associated with congenital complemnet C4 deficiency. Reduced levels of components of the classic pathway complement(s)(C1, C2, C4, C3) are common after such activation, Systemic lupus erythematosus , acute serum sickness and conditions associated with circulating immune complexes.

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194-42-1 $ 164.00 1 mg
194-42-10 $ 1,216.00 10 mg
194-42-100 $ 7,975.00 100 mg