Complement Component 4c (C4c)

Catalogue Number: 194-41
Product Name Complement Component 4c
Source Human Plasma
Catalogue Number 194-41
Purity > 95% (SDS-PAGE)
Form Liquid
Protein 1.0 - 5.0 mg/mL (E0.1%280nm = 0.92)
Identity Confirmed by Western Blot
Formulation 0.2 micron filtered frozen solution in phosphate buffered saline, pH 7.4.
Related Products GC4-80A - anti-Human Complement C4 polyclonal antibody
194-42 - Complement C4c antigen from human plasma - Lyophilized
194-31 - Complement C3c antigen from human plasma
Storage -20°C
Recertification 2 years
Infectious Disease Testing Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV, HBsAg, HIV-1 (NAT), HBV (NAT), HCV (NAT), and syphilis by FDA approved methods.
Product Details Complement C4 (200 kDa) is composed of three polypeptide chains – α (93 kDa), β (78 kDa), and γ (33 kDa). During complement activation, C4 is cleaved by the serine protease C1s to C4a (9 kDa) and C4b (190 kDa). C4b is further cleaved by factor I to C4d (45 kDa) and C4c (140 kDa). The current protocol yields C4c, however intact C4 and/or C4b and C4d may be co-purified.
Synonyms C4, Complement C4, C4c
Molecular Weight 147,000
Gene C4A, C4B
Gene Synonyms DAMC-258G8.6, C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG, DADB-112B14.11-001, C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4F, CH, CO4, CPAMD3
Gene ID 720, 721

Lee Biosolutions sells Human Complement C4c (C4c) for research and diagnostic manufacturing.

Custom preparations, technical support, bulk quantities and aliquoting available, email for more details.

Human Complement proteins: It is thought that the complement system might play a role in many diseases with an immune component, such as Alzheimer's disease, asthma, lupus erythematosus, various forms of arthritis, autoimmune heart disease and multiple sclerosis.

Deficiencies of the terminal pathway predispose to both autoimmune disease and infections (particularly meningitis).

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194-41-0.1 $ 65.00 100 ug
194-41-1 $ 137.00 1 mg
194-41-10 $ 1,001.00 10 mg
194-41-100 $ 6,984.00 100 mg