Complement Component 3c (C3c)

Product Name	Complement Component 3c
Source	Human Plasma
Catalogue Number	194-32
Purity	> 95% (SDS-PAGE)
Form	Lyophilized
Protein	Reported in mg/vial (A₂₈₀ E^0.1%=1.03)
Formulation	Lyophilized from phosphate buffered saline, pH 7.4.
Related Products	GC3-80A - anti-Human Complement C3 polyclonal antibody 194-31 - Complement C3c antigen from human plasma - Liquid 194-41 - Complement C4c antigen from human plasma
Storage	-20°C
Recertification	4 years
Infectious Disease Testing	Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV, HBsAg, HIV-1 (NAT), HBV (NAT), HCV (NAT), and syphilis by FDA approved methods.
Product Details	Complement C3 is synthesized as a single chain of 185 kDa and is processed in the plasma to a disulfide-linked heterodimer consisting of an α-chain (115 kDa) and a β-chain (70 kDa). During complement activation, C3 is cleaved by C3 convertases to C3a (9 kDa) and C3b (176 kDa) comprised of the large C-terminal portion of the α-chain and the β-chain. Factor I further cleaves C3b into C3c (140 kDa), C3d (35 kDa), and C3g (7 kDa). The current protocol yields C3c, however intact C3 and/or C3a/C3b may be co-purified.
Molecular Weight	138,000
Synonyms	C3c
Gene	C3
Gene ID	718
Gene Synonyms	AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1