Thyroid Peroxidase (TPO)

Catalogue Number: 560-11R
Product Name Thyroid Peroxidase
Source Recombinant
Catalogue Number 560-11R
Purity > 96% (SDS-PAGE)
Form Liquid
Expression System Baculoviridae
Protein > 0.5 mg/mL
Sequence Full-length human sequence
Tags None
Formulation Solution in Tris HCl, NaCl, KI and glycerol, pH 7.6.
Related Products 581-10 - Thyroxine (T4) antigen
528-11 - Thyroglobulin (Tg) antigen
996-51 - Thyroid Stimulating Hormone (TSH) antigen
Storage -70°C
Recertification 2 years
Application Autoimmune capture in commercial assays
Synonyms r-hTPO, r-TPO,TPO
Molecular Weight ~104,000

Human Thyroid peroxidase (TPO) is an enzyme mainly expressed in the thyroid that liberates iodine for addition onto tyrosine residues on Thyroglobulin for the production of thyroxine (thyroid hormone).

Thyroid Peroxidase is the antigenic determinant of the thyroid microsome associated with anti-TPO autoantibodies. Anti-TPO is an important secondary marker in the diagnosis of Grave's and Hashimoto disease. Thyroid antibodies are also assiciated with infertility and fetal loss.

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