Haptoglobin 2-2 (Hp2-2)
| Product Name | Haptoglobin 2-2 |
| Source | Human Plasma |
| Catalogue Number | 330-13 |
| Purity | > 95% (SDS-PAGE) |
| Form | Lyophilized |
| Protein | Reported in mg/vial (A280 E0.1%=1.20) |
| Phenotype | 2-2 |
| Appearance | White to near white |
| Reconstitution | Centrifuge briefly prior to opening and reconstitute with deionized water in the provided container for full recovery. Aliquot and freeze at -20°C after reconstitution. |
| Related Products | 330-11 - Haptoglobin antigen 330-12 - Haptoglobin 1-1 antigen |
| Storage | -20°C |
| Recertification | 5 years |
| Molecular Weight | 170,000-900,000 |
| Synonyms | Hp2-2 |
| CAS Number | 9087-69-8 |
Lee Biosolutions is the leading manufacturer of Human Haptoglobin for research and diagnostics.
Custom preparations, technical support, bulk quantities and aliquoting available, email Info@leebio.com for more details.
In blood plasma, haptoglobin binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen).
In clinical settings, the haptoglobulin assay is used to screen for and monitor intravascular hemolytic anemia . In intravascular hemolysis, free hemoglobin will be released into circulation and hence haptoglobin will bind the Hb. This causes a decline in Hp levels. Conversely, in extravascular hemolysis the reticuloendothelial system, especially splenic monocytes, phagocytose the erythrocytes and hemoglobin is not released into circulation; serum haptoglobin levels are therefore normal.
Lee Biosolutions, Inc
