Brain Natriuretic Peptide-32 (BNP-32)

Catalogue Number: 129-10
Product Name Brain Natriutetic Peptide 32
Source Synthetic
Source Note Human Sequence
Catalogue Number 129-10
Purity > 95% (HPLC)
Form Lyophilized
Assay > 65% (Elemental Analysis)
Appearance White lyophilisate
Solubility Clear and colorless in 1 mg/mL water
Related Products 129-15 - NT-ProBNP antigen
991-24-S-NTPBNP - NT-ProBNP serum samples from human patients
Storage -20°C
Recertification 5 years
Synonyms BNP-32, Nesiritide, B-type natriuretic peptide, GC-B
Formula C143H244N50O42S4
Molecular Mass 3464.09
CAS Number 114471-18-0

Custom preparations, technical support, bulk quantities and aliquoting available, email for more details.

Human Brain Natriuretic Peptide BNP-32 also known as B-type natriuretic peptide or GC-B has a Peptide Sequence: H-Ser-Pro-Lys-Met-Val-Gin-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-lle-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His-OH (disulfide bond).

Brain Natriuretic Peptide (BNP-32) is a 32-amino-acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of myocytes (heart muscles cells) in the ventricles. At the time of release, a co-secreted 76 amino acid n-terminal fragment (NT-proBNP) is also released with B-type natriuretic peptide. B-type natriuretic peptide BNP binds to and activates NPRA in a similar fashion to atrial natriuretic peptide but with 10-fold lower affinity. The biological half-life of BNP however, is twice as long as that of ANP. Both ANP and BNP have limited ability to bind and activate NPRB.

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