Complement Component 3c (C3c)

Catalogue Number: 194-32
Product Name Complement Component 3c
Source Human Plasma
Catalogue Number 194-32
Purity > 95% (SDS-PAGE)
Form Lyophilized
Protein Reported in mg/vial (A280 E0.1%=1.03)
Formulation Lyophilized from phosphate buffered saline, pH 7.4.
Related Products GC3-80A - anti-Human Complement C3 polyclonal antibody
194-31 - Complement C3c antigen from human plasma - Liquid
194-41 - Complement C4c antigen from human plasma
Storage -20°C
Recertification 4 years
Infectious Disease Testing Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV, HBsAg, HIV-1 (NAT), HBV (NAT), HCV (NAT), and syphilis by FDA approved methods.
Product Details Complement C3 is synthesized as a single chain of 185 kDa and is processed in the plasma to a disulfide-linked heterodimer consisting of an α-chain (115 kDa) and a β-chain (70 kDa). During complement activation, C3 is cleaved by C3 convertases to C3a (9 kDa) and C3b (176 kDa) comprised of the large C-terminal portion of the α-chain and the β-chain. Factor I further cleaves C3b into C3c (140 kDa), C3d (35 kDa), and C3g (7 kDa). The current protocol yields C3c, however intact C3 and/or C3a/C3b may be co-purified.
Molecular Weight 138,000
Synonyms C3c
Gene C3
Gene ID 718
Gene Synonyms AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1

Lee Biosolutions sells Human Complement C3 (C3) for research and diagnostic manufacturing.

Custom preparations, technical support, bulk quantities and aliquoting available, email for more details.

Human Complement proteins: It is thought that the complement system might play a role in many diseases with an immune component, such as Alzheimer's disease, asthma, lupus erythematosus, various forms of arthritis, autoimmune heart disease and multiple sclerosis.

Deficiencies of the terminal pathway predispose to both autoimmune disease and infections (particularly meningitis).

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194-32-1 $ 145.00 1 mg
194-32-10 $ 1,171.00 10 mg
194-32-100 $ 7,092.00 100 mg